Product Name :
5Z-7-Oxozeaenol
Description:
5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, respectively.
CAS:
253863-19-3
Molecular Weight:
362.37
Formula:
C19H22O7
Chemical Name:
(3S, 8S, 9S)-8, 9, 16-trihydroxy-14-methoxy-3-methyl-3, 4, 7, 8, 9, 10-hexahydro-1H-2-benzoxacyclotetradecine-1, 7-dione
Smiles :
C[C@H]1CC=CC(=O)[C@@H](O)[C@@H](O)CC=CC2=CC(=CC(O)=C2C(=O)O1)OC |c:3,t:12|
InChiKey:
NEQZWEXWOFPKOT-UXGSFGIESA-N
InChi :
InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4-,7-3-/t11-,15-,18+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, respectively.|Product information|CAS Number: 253863-19-3|Molecular Weight: 362.37|Formula: C19H22O7|Synonym:|FR148083|L783279|LL-Z 1640-2|Chemical Name: (3S, 8S, 9S)-8, 9, 16-trihydroxy-14-methoxy-3-methyl-3, 4, 7, 8, 9, 10-hexahydro-1H-2-benzoxacyclotetradecine-1, 7-dione|Smiles: C[C@H]1CC=CC(=O)[C@@H](O)[C@@H](O)CC=CC2=CC(=CC(O)=C2C(=O)O1)OC |c:3,t:12||InChiKey: NEQZWEXWOFPKOT-UXGSFGIESA-N|InChi: InChI=1S/C19H22O7/c1-11-5-3-7-14(20)18(23)15(21)8-4-6-12-9-13(25-2)10-16(22)17(12)19(24)26-11/h3-4,6-7,9-11,15,18,21-23H,5,8H2,1-2H3/b6-4-,7-3-/t11-,15-,18+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (137.{{Water-18O} site|{Water-18O} {Isotope-Labeled Compounds}|{Water-18O} Epigenetics|{Water-18O} Protocol|{Water-18O} References|{Water-18O} supplier} 98 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Adalimumab} MedChemExpress|{Adalimumab} TNF Receptor|{Adalimumab} Protocol|{Adalimumab} Data Sheet|{Adalimumab} custom synthesis|{Adalimumab} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:33094701 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|5Z-7-Oxozeaenol is a potent irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 (TAK1, IC50, 8.1 nM), less active on MEK1 (IC50, 411 nM). 5Z-7-Oxozeaenol prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. 5Z-7-Oxozeaenol is also an inhibitor of VEGF-R2, with an IC50 of 52 nM. 5Z-7-Oxozeaenol has inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE and SRC, with IC50s of 110, 170, 340, 6300 and 6600 nM, respectively. 5Z-7-Oxozeaenol inhibits JNK/p38 paythway, but it is not a direct inhibitor and is signal specific. 5Z-7-Oxozeaenol suppresses the PMA-induced AP-1 activity almost to the basal level in the KT cells, but has no effects on IL-1-induced NF-kB activity in the KK cells.|References:|Ninomiya-Tsuji J, et al. A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J Biol Chem. 2003 May 16;278(20):18485-90.Dakas PY, et al. Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors. Angew Chem Int Ed Engl. 2007;46(36):6899-902.Takehana K, et al. A radicicol-related macrocyclic nonaketide compound, antibiotic LL-Z1640-2, inhibits the JNK/p38 pathways in signal-specific manner. Biochem Biophys Res Commun. 1999 Apr 2;257(1):19-23.Products are for research use only. Not for human use.|
