Product Name :
Sulfosuccinimidyl oleate sodium
Description:
Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect.
CAS:
Molecular Weight:
481.58
Formula:
C22H36NNaO7S
Chemical Name:
2,5-dioxo-3-[(sodiooxy)sulfonyl]pyrrolidin-1-yl (9Z)-octadec-9-enoate
Smiles :
CCCCCCCC/C=C\CCCCCCCC(=O)ON1C(=O)C(CC1=O)S(=O)(=O)O[Na]
InChiKey:
FZVVLJSNKVOPRF-KVVVOXFISA-M
InChi :
InChI=1S/C22H37NO7S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(25)30-23-20(24)18-19(22(23)26)31(27,28)29;/h9-10,19H,2-8,11-18H2,1H3,(H,27,28,29);/q;+1/p-1/b10-9-;
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Sulfosuccinimidyl oleate sodium (Sulfo-N-succinimidyl oleate sodium) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate sodium is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate sodium binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect.|Product information|Molecular Weight: 481.58|Formula: C22H36NNaO7S|Chemical Name: 2,5-dioxo-3-[(sodiooxy)sulfonyl]pyrrolidin-1-yl (9Z)-octadec-9-enoate|Smiles: CCCCCCCC/C=C\CCCCCCCC(=O)ON1C(=O)C(CC1=O)S(=O)(=O)O[Na]|InChiKey: FZVVLJSNKVOPRF-KVVVOXFISA-M|InChi: InChI=1S/C22H37NO7S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(25)30-23-20(24)18-19(22(23)26)31(27,28)29;/h9-10,19H,2-8,11-18H2,1H3,(H,27,28,29);/q;+1/p-1/b10-9-;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 62.5 mg/mL (129.78 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Sulfosuccinimidyl oleate (20 μM and 50 μM, 24 hours) alone does not alter the cellular viability.{{Polatuzumab vedotin} site|{Polatuzumab vedotin} Antibody-drug Conjugate/ADC Related|{Polatuzumab vedotin} Technical Information|{Polatuzumab vedotin} Formula|{Polatuzumab vedotin} custom synthesis|{Polatuzumab vedotin} Epigenetics} Exposure to 100 ng/ml LPS+5 ng/mL IFNγ modestly, yet significantly reduces the viability of the BV2 cells.{{Cy5-DBCO} MedChemExpress|{Cy5-DBCO} {Fluorescent Dye}|{Cy5-DBCO} Biological Activity|{Cy5-DBCO} In Vitro|{Cy5-DBCO} custom synthesis|{Cy5-DBCO} Cancer} Co-treatment with Sulfosuccinimidyl oleate prevents the LPS+IFNγ-induced reduction in the cell viability.PMID:24883330 Sulfosuccinimidyl oleate (50 μM, 24 hours) co-treatment significantly reduces the LPS+IFNγ-induced expression of NOS2 and COX-2 in BV2 cells. Western blot analysis reveals a significant LPS/IFNγ-induced upregulation in the phosphorylated form of the p38, which is prevented by co-treatment with Sulfosuccinimidyl oleate (50 μM, 24 hours).|In Vivo:|Sulfosuccinimidyl oleate (50 mg/kg; administered once by single oral gavage) significantly reduces the cortical ischemic infarct size compared to vehicle-treated controls in male BALB/cABom mice with pMCAo model. In addition, Sulfosuccinimidyl oleate at 50 mg/kg is suitable to see a beneficial effect after stroke.|Products are for research use only. Not for human use.|
