Product Name :
HEAT hydrochloride
Description:
HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively.
CAS:
30007-39-7
Molecular Weight:
331.84
Formula:
C19H22ClNO2
Chemical Name:
[2-(4-hydroxyphenyl)ethyl]({[(2R)-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl]methyl})azanium chloride
Smiles :
[Cl-].OC1C=CC(CC[NH2+]C[C@H]2CCC3=CC=CC=C3C2=O)=CC=1
InChiKey:
VCZXZECZIRGUCZ-PKLMIRHRSA-N
InChi :
InChI=1S/C19H21NO2.ClH/c21-17-9-5-14(6-10-17)11-12-20-13-16-8-7-15-3-1-2-4-18(15)19(16)22;/h1-6,9-10,16,20-21H,7-8,11-13H2;1H/t16-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Nimotuzumab} MedChemExpress|{Nimotuzumab} Protein Tyrosine Kinase/RTK|{Nimotuzumab} Biological Activity|{Nimotuzumab} Purity|{Nimotuzumab} supplier|{Nimotuzumab} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively.|Product information|CAS Number: 30007-39-7|Molecular Weight: 331.84|Formula: C19H22ClNO2|Chemical Name: [2-(4-hydroxyphenyl)ethyl]({[(2R)-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl]methyl})azanium chloride|Smiles: [Cl-].OC1C=CC(CC[NH2+]C[C@H]2CCC3=CC=CC=C3C2=O)=CC=1|InChiKey: VCZXZECZIRGUCZ-PKLMIRHRSA-N|InChi: InChI=1S/C19H21NO2.ClH/c21-17-9-5-14(6-10-17)11-12-20-13-16-8-7-15-3-1-2-4-18(15)19(16)22;/h1-6,9-10,16,20-21H,7-8,11-13H2;1H/t16-;/m1.{{Romosozumab} web|{Romosozumab} Technical Information|{Romosozumab} In Vivo|{Romosozumab} supplier|{Romosozumab} Cancer} /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24182988 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BE2254 inhibits (-)-noradrenaline-mediated increases in gluconeogenesis with K,sub>B of 0.74 nM. The alpha-1 selective antagonist [125I]BE2254 is used to specifically label a single class of binding sites with a dissociation constant of 131.0 pM and a maximal binding capacity of 17.6 fmol/mg of protein. Catecholamines compete for [125I]BE2254 binding stereospecifically and with the characteristic alpha adrenergic potency series of (-)-epinephrine greater than (-)-norepinephrine much greater than (-)-isoproterenol. The alpha-1 selective antagonist prazosin (Kd=2.4 nM) is much more potent in competing for [125I]BE2254 binding than is the alpha-2 selective antagonist yohimbine (Kd=2900 nM).|Products are for research use only. Not for human use.|
