Product Name :
AZD2932
Description:
AZD-2932 is a high affinity inhibitor of VEFGR-2 and PDGFR. AZD-2932 has a balanced ~ 1:1 ratio of activity vs both VEGFR-2 and PDGFRβ and shows IC50 values of 8 and 4 nM against the two enzymes, respectively. It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases. The pharmacokinetic behavior and the preclinical antitumor activity in nude mice bearing C6 rat glial tumors indicate that 31 has the potential to become an antiangiogenic agent in the clinic.
CAS:
883986-34-3
Molecular Weight:
447.49
Formula:
C24H25N5O4
Chemical Name:
2-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-N-[1-(propan-2-yl)-1H-pyrazol-4-yl]acetamide
Smiles :
COC1=CC2=C(N=CN=C2C=C1OC)OC1C=CC(CC(=O)NC2C=NN(C=2)C(C)C)=CC=1
InChiKey:
TWYCZJMOEMMCGC-UHFFFAOYSA-N
InChi :
InChI=1S/C24H25N5O4/c1-15(2)29-13-17(12-27-29)28-23(30)9-16-5-7-18(8-6-16)33-24-19-10-21(31-3)22(32-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZD-2932 is a high affinity inhibitor of VEFGR-2 and PDGFR. AZD-2932 has a balanced ~ 1:1 ratio of activity vs both VEGFR-2 and PDGFRβ and shows IC50 values of 8 and 4 nM against the two enzymes, respectively. It is also active on c-Kit and FLT3 with good selectivity on a panel of kinases. The pharmacokinetic behavior and the preclinical antitumor activity in nude mice bearing C6 rat glial tumors indicate that 31 has the potential to become an antiangiogenic agent in the clinic.{{ALC-0159} web|{ALC-0159} Liposome|{ALC-0159} Epigenetics|{ALC-0159} Protocol|{ALC-0159} Description|{ALC-0159} supplier} |Product information|CAS Number: 883986-34-3|Molecular Weight: 447.{{Valecobulin hydrochloride} MedChemExpress|{Valecobulin hydrochloride} Cytoskeleton|{Valecobulin hydrochloride} Biological Activity|{Valecobulin hydrochloride} Formula|{Valecobulin hydrochloride} custom synthesis|{Valecobulin hydrochloride} Autophagy} 49|Formula: C24H25N5O4|Chemical Name: 2-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-N-[1-(propan-2-yl)-1H-pyrazol-4-yl]acetamide|Smiles: COC1=CC2=C(N=CN=C2C=C1OC)OC1C=CC(CC(=O)NC2C=NN(C=2)C(C)C)=CC=1|InChiKey: TWYCZJMOEMMCGC-UHFFFAOYSA-N|InChi: InChI=1S/C24H25N5O4/c1-15(2)29-13-17(12-27-29)28-23(30)9-16-5-7-18(8-6-16)33-24-19-10-21(31-3)22(32-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:28322188 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
