Product Name :
PHA-680632
Description:
PHA-680632 is a is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. PHA-680632 is also the first representative of a new class of Aurora inhibitors with a high potential for further development as an anticancer therapeutic. PHA-680632 is active on a wide range of cancer cell lines and shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses.
CAS:
398493-79-3
Molecular Weight:
501.62
Formula:
C28H35N7O2
Chemical Name:
N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxamide
Smiles :
CN1CCN(CC1)C1C=CC(=CC=1)C(=O)NC1=NNC2CN(CC=21)C(=O)NC1C(CC)=CC=CC=1CC
InChiKey:
OBWNXGOQPLDDPS-UHFFFAOYSA-N
InChi :
InChI=1S/C28H35N7O2/c1-4-19-7-6-8-20(5-2)25(19)29-28(37)35-17-23-24(18-35)31-32-26(23)30-27(36)21-9-11-22(12-10-21)34-15-13-33(3)14-16-34/h6-12H,4-5,13-18H2,1-3H3,(H,29,37)(H2,30,31,32,36)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{AK-7} MedChemExpress|{AK-7} Cell Cycle/DNA Damage|{AK-7} Purity & Documentation|{AK-7} Data Sheet|{AK-7} supplier|{AK-7} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PHA-680632 is a is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. PHA-680632 is also the first representative of a new class of Aurora inhibitors with a high potential for further development as an anticancer therapeutic.{{Anti-Mouse IL-1a Antibody} MedChemExpress|{Anti-Mouse IL-1a Antibody} Integrin|{Anti-Mouse IL-1a Antibody} Biological Activity|{Anti-Mouse IL-1a Antibody} Purity|{Anti-Mouse IL-1a Antibody} supplier|{Anti-Mouse IL-1a Antibody} Epigenetic Reader Domain} PHA-680632 is active on a wide range of cancer cell lines and shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses.PMID:26895888 |Product information|CAS Number: 398493-79-3|Molecular Weight: 501.62|Formula: C28H35N7O2|Chemical Name: N-(2,6-diethylphenyl)-3-(4-(4-methylpiperazin-1-yl)benzamido)pyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxamide|Smiles: CN1CCN(CC1)C1C=CC(=CC=1)C(=O)NC1=NNC2CN(CC=21)C(=O)NC1C(CC)=CC=CC=1CC|InChiKey: OBWNXGOQPLDDPS-UHFFFAOYSA-N|InChi: InChI=1S/C28H35N7O2/c1-4-19-7-6-8-20(5-2)25(19)29-28(37)35-17-23-24(18-35)31-32-26(23)30-27(36)21-9-11-22(12-10-21)34-15-13-33(3)14-16-34/h6-12H,4-5,13-18H2,1-3H3,(H,29,37)(H2,30,31,32,36)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
