Product Name :
(R)-(-)-Rolipram
Description:
(R)-(-)-rolipram R-enantiomer of rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 022 M and 25-fold more potent than-rolipram IC50 258 M in inhibiting membrane-bound PDE 4
CAS:
85416-75-7
Molecular Weight:
275.34
Formula:
C16H21NO3
Chemical Name:
(4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Smiles :
COC1=CC=C(C=C1OC1CCCC1)[C@H]1CC(=O)NC1
InChiKey:
HJORMJIFDVBMOB-LBPRGKRZSA-N
InChi :
InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
(R)-(-)-rolipram R-enantiomer of rolipram is a potent and cAMP-specific PDE4 inhibitor with IC50 of 022 M and 25-fold more potent than-rolipram IC50 258 M in inhibiting membrane-bound PDE 4|Product information|CAS Number: 85416-75-7|Molecular Weight: 275.34|Formula: C16H21NO3|Synonym:|(R)-Rolipram|(-)-Rolipram|Chemical Name: (4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one|Smiles: COC1=CC=C(C=C1OC1CCCC1)[C@H]1CC(=O)NC1|InChiKey: HJORMJIFDVBMOB-LBPRGKRZSA-N|InChi: InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)/t12-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (363.19 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.{{Verubecestat} medchemexpress|{Verubecestat} Beta-secretase|{Verubecestat} Immunology/Inflammation|{Verubecestat} Purity & Documentation|{Verubecestat} In stock|{Verubecestat} supplier} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Baricitinib} medchemexpress|{Baricitinib} JAK/STAT Signaling|{Baricitinib} Biological Activity|{Baricitinib} References|{Baricitinib} supplier|{Baricitinib} Autophagy} |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The increase of cAMP synthesis with the adenylate cyclase activator forskolin or the decrease of cAMP hydrolysis by the phosphodiesterase inhibitors Isobutylmethylxanthine (IBMX) and (R)-(-)-Rolipram (MedChem Express) suppresses caspase-1 cleavage and IL-1β secretion in a dose-dependent manner.PMID:23522542 |References:|Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944.Products are for research use only. Not for human use.|
