Product Name :
PF-03715455
Description:
PF-03715455 is a potent inhaled p38 MAPK inhibitor. PF-03715455 shows some selectivity for p38α over p38β with respective IC50 values of 0.88 and 23 nM. PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease).
CAS:
1056164-52-3
Molecular Weight:
700.27
Formula:
C35H34ClN7O3S2
Chemical Name:
3-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-1-({2-[(3-{2-[(2-hydroxyethyl)sulfanyl]phenyl}-[1,2,4]triazolo[4,3-a]pyridin-6-yl)sulfanyl]phenyl}methyl)urea
Smiles :
CC(C)(C)C1C=C(NC(=O)NCC2=CC=CC=C2SC2=CN3C(=NN=C3C=C2)C2=CC=CC=C2SCCO)N(N=1)C1=CC=C(O)C(Cl)=C1
InChiKey:
VGEXRDWWPSGZDH-UHFFFAOYSA-N
InChi :
InChI=1S/C35H34ClN7O3S2/c1-35(2,3)30-19-32(43(41-30)23-12-14-27(45)26(36)18-23)38-34(46)37-20-22-8-4-6-10-28(22)48-24-13-15-31-39-40-33(42(31)21-24)25-9-5-7-11-29(25)47-17-16-44/h4-15,18-19,21,44-45H,16-17,20H2,1-3H3,(H2,37,38,46)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PF-03715455 is a potent inhaled p38 MAPK inhibitor. PF-03715455 shows some selectivity for p38α over p38β with respective IC50 values of 0.88 and 23 nM. PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease).{{Opipramol} site|{Opipramol} Neuronal Signaling|{Opipramol} Protocol|{Opipramol} Formula|{Opipramol} custom synthesis|{Opipramol} Epigenetic Reader Domain} |Product information|CAS Number: 1056164-52-3|Molecular Weight: 700.{{Isatuximab} site|{Isatuximab} Apoptosis|{Isatuximab} Biological Activity|{Isatuximab} Data Sheet|{Isatuximab} manufacturer|{Isatuximab} Epigenetic Reader Domain} 27|Formula: C35H34ClN7O3S2|Chemical Name: 3-[3-tert-butyl-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl]-1-({2-[(3-{2-[(2-hydroxyethyl)sulfanyl]phenyl}-[1,2,4]triazolo[4,3-a]pyridin-6-yl)sulfanyl]phenyl}methyl)urea|Smiles: CC(C)(C)C1C=C(NC(=O)NCC2=CC=CC=C2SC2=CN3C(=NN=C3C=C2)C2=CC=CC=C2SCCO)N(N=1)C1=CC=C(O)C(Cl)=C1|InChiKey: VGEXRDWWPSGZDH-UHFFFAOYSA-N|InChi: InChI=1S/C35H34ClN7O3S2/c1-35(2,3)30-19-32(43(41-30)23-12-14-27(45)26(36)18-23)38-34(46)37-20-22-8-4-6-10-28(22)48-24-13-15-31-39-40-33(42(31)21-24)25-9-5-7-11-29(25)47-17-16-44/h4-15,18-19,21,44-45H,16-17,20H2,1-3H3,(H2,37,38,46)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:35954127 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PF-03715455 is a moderate inhibitor of CYP1A2, CYP2C19, and CYP2D6 and a potent inhibitor of CYP’s 2C9 and CYP3A4.|In Vivo:|PF-03715455 treatment shows that the Vss and T1/2 are 0.19 L/kg, 1 hour, respectively.|Products are for research use only. Not for human use.|
