Product Name :
Setogepram
Description:
Setogepram (PBI-4050) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Setogepram (PBI-4050) decreases renal, liver and pancreatic fibrosis. Setogepram (PBI-4050) exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions.
CAS:
1002101-19-0
Molecular Weight:
206.28
Formula:
C13H18O2
Chemical Name:
2-(3-pentylphenyl)acetic acid
Smiles :
CCCCCC1C=CC=C(CC(O)=O)C=1
InChiKey:
PEGQOIGYZLJMIB-UHFFFAOYSA-N
InChi :
InChI=1S/C13H18O2/c1-2-3-4-6-11-7-5-8-12(9-11)10-13(14)15/h5,7-9H,2-4,6,10H2,1H3,(H,14,15)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Setogepram (PBI-4050) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84.{{Oleuropein} web|{Oleuropein} PPAR|{Oleuropein} Purity & Documentation|{Oleuropein} In Vivo|{Oleuropein} custom synthesis|{Oleuropein} Epigenetic Reader Domain} Setogepram (PBI-4050) decreases renal, liver and pancreatic fibrosis.{{Pioglitazone} site|{Pioglitazone} Metabolic Enzyme/Protease|{Pioglitazone} Purity & Documentation|{Pioglitazone} In Vitro|{Pioglitazone} supplier|{Pioglitazone} Epigenetics} Setogepram (PBI-4050) exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions.PMID:25955218 |Product information|CAS Number: 1002101-19-0|Molecular Weight: 206.28|Formula: C13H18O2|Chemical Name: 2-(3-pentylphenyl)acetic acid|Smiles: CCCCCC1C=CC=C(CC(O)=O)C=1|InChiKey: PEGQOIGYZLJMIB-UHFFFAOYSA-N|InChi: InChI=1S/C13H18O2/c1-2-3-4-6-11-7-5-8-12(9-11)10-13(14)15/h5,7-9H,2-4,6,10H2,1H3,(H,14,15)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Setogepram (PBI-4050; 500 µM; 24 hours) inhibits TGF-β (10 ng/mL)-activated human hepatic stellate cells (HSCs) proliferation. Setogepram (PBI-4050; 250 or 500 µM; 24hours) dose-dependently arrests HSCs at the G0/G1 phase without inducing apoptosis.|In Vivo:|Setogepram (PBI-4050; 100 mg/kg/day; gavage from 8-20 weeks of age) markedly decreases hyperglycemia and markedly improvea glucose tolerance in type 2 diabetes eNOS-/-db/db mice.|Products are for research use only. Not for human use.|
