Product Name :
ATB-343
Description:
ATB-343, also named as indomethacin, is an H2S-releasing derivative of indomethacin . Hydrogen sulfide (H2S) is a newly recognized signaling molecule with potent cytoprotective actions. Hydrogen sulfide has been involved in mediating many physiological processes, such as the maintenance of gastrointestinal mucosal defense and repair. Hydrogen sulfide also exerts many anti-inflammatory effects, including inhibition of leukocyte adherence to the vascular endothelium and leukocyte migration to sites of inflammation . In vitro: Indomethacin enhanced the NK cell activity in vitro by blocking the prostaglandin production of monocytes . In vivo: In rats, oral administration of ATB-343 significantly inhibited gastric prostaglandin synthesis and systemic COX-1 activity . Indomethacin was a potent inhibitor of prostaglandin synthesis. Indomethacin suppressed in vivo thyroid hormone secretion and cholera toxin-induced intestinal fluid accumulation. Indomethacin in submicromolar concentrations inhibited cyclic AMP-dependent protein kinase and endogenous protein phosphorylation . Clinical trials: Indomethacin has entered clinical trial in Alzheimer’s disease .
CAS:
1000700-26-4
Molecular Weight:
566.11
Formula:
C28H20ClNO4S3
Chemical Name:
4-(3-sulfanylidene-3H-1,2-dithiol-5-yl)phenyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
Smiles :
CC1=C(CC(=O)OC2C=CC(=CC=2)C2=CC(=S)SS2)C2=CC(=CC=C2N1C(=O)C1C=CC(Cl)=CC=1)OC
InChiKey:
SJLZXDOBSHEDIF-UHFFFAOYSA-N
InChi :
InChI=1S/C28H20ClNO4S3/c1-16-22(14-26(31)34-20-9-5-17(6-10-20)25-15-27(35)37-36-25)23-13-21(33-2)11-12-24(23)30(16)28(32)18-3-7-19(29)8-4-18/h3-13,15H,14H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Icatibant} site|{Icatibant} Bradykinin Receptor|{Icatibant} Protocol|{Icatibant} In Vivo|{Icatibant} manufacturer|{Icatibant} Cancer}
Shelf Life:
≥12 months if stored properly.{{Oxacillin sodium} site|{Oxacillin sodium} Antibiotic|{Oxacillin sodium} Biological Activity|{Oxacillin sodium} Formula|{Oxacillin sodium} supplier|{Oxacillin sodium} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ATB-343, also named as indomethacin, is an H2S-releasing derivative of indomethacin . Hydrogen sulfide (H2S) is a newly recognized signaling molecule with potent cytoprotective actions. Hydrogen sulfide has been involved in mediating many physiological processes, such as the maintenance of gastrointestinal mucosal defense and repair. Hydrogen sulfide also exerts many anti-inflammatory effects, including inhibition of leukocyte adherence to the vascular endothelium and leukocyte migration to sites of inflammation . In vitro: Indomethacin enhanced the NK cell activity in vitro by blocking the prostaglandin production of monocytes . In vivo: In rats, oral administration of ATB-343 significantly inhibited gastric prostaglandin synthesis and systemic COX-1 activity . Indomethacin was a potent inhibitor of prostaglandin synthesis. Indomethacin suppressed in vivo thyroid hormone secretion and cholera toxin-induced intestinal fluid accumulation. Indomethacin in submicromolar concentrations inhibited cyclic AMP-dependent protein kinase and endogenous protein phosphorylation .PMID:23800738 Clinical trials: Indomethacin has entered clinical trial in Alzheimer’s disease .|Product information|CAS Number: 1000700-26-4|Molecular Weight: 566.11|Formula: C28H20ClNO4S3|Chemical Name: 4-(3-sulfanylidene-3H-1,2-dithiol-5-yl)phenyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate|Smiles: CC1=C(CC(=O)OC2C=CC(=CC=2)C2=CC(=S)SS2)C2=CC(=CC=C2N1C(=O)C1C=CC(Cl)=CC=1)OC|InChiKey: SJLZXDOBSHEDIF-UHFFFAOYSA-N|InChi: InChI=1S/C28H20ClNO4S3/c1-16-22(14-26(31)34-20-9-5-17(6-10-20)25-15-27(35)37-36-25)23-13-21(33-2)11-12-24(23)30(16)28(32)18-3-7-19(29)8-4-18/h3-13,15H,14H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
