Gnificant.Author Contributions: Conceptualization, J.M.K.; methodology, J.I.J.; computer software, J.I.J.; validation, J.I.J. and J.M.K.; formal analysis, J.I.J., K.H.L. and J.M.K.; investigation, J.M.K.; sources, J.M.K. and K.H.L.; data curation, J.I.J., and J.M.K.; writing–original draft preparation, J.M.K.; writing–review and editing, J.M.K.; visualization, J.I.J.; supervision, J.M.K.; project administration, J.M.K.; funding acquisition, J.M.K. and K.H.L. All authors have study and agreed for the published version with the manuscript. Funding: This analysis was supported by the basic Science Analysis Program by way of the National Investigation Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technologies (MEST) (NRF-2021R1F1A1045550), Republic of Korea. Institutional Review Board Statement: Not applicable. Informed Consent Statement: Not applicable. Conflicts of Interest: The authors have no conflict of interest to declare.International Journal ofMolecular SciencesReviewIntermolecular Diels-Alder Cycloadditions of Furfural-Based Chemical compounds from Renewable Sources: A Concentrate on the Regio- and Diastereoselectivity inside the Reaction with AlkenesKonstantin I. Galkin 1,two and Valentine P. Ananikov 1, Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospekt 47, 119991 Moscow, Russia; [email protected] Laboratory of Functional Composite Supplies, Bauman Moscow State Technical University, 2nd Baumanskaya Street 5/1, 105005 Moscow, Russia Correspondence: [email protected]: Galkin, K.I.; Ananikov, V.P. Intermolecular Diels-Alder Cycloadditions of Furfural-Based Chemical substances from Renewable Sources: A Focus around the Regio- and Diastereoselectivity inside the Reaction with Alkenes. Int. J. Mol. Sci. 2021, 22, 11856. 10.3390/ Trospium EP impurity C-d8 Autophagy ijms222111856 Academic Editor: Vladim K en r Received: 14 October 2021 Accepted: 29 October 2021 Published: 1 NovemberAbstract: A current robust trend toward green and sustainable chemistry has promoted the intensive use of renewable carbon sources for the Linoleyl methane sulfonate Purity & Documentation production of polymers, biofuels, chemical substances, monomers and other important solutions. The Diels-Alder reaction is of good importance inside the chemistry of renewable resources and delivers an atom-economic pathway for fine chemical synthesis and for the production of materials. The biobased furans furfural and 5-(hydroxymethyl)furfural, which could be very easily obtained in the carbohydrate a part of plant biomass, have been recognized as “platform chemicals” that can aid to replace the current oil-based refining to biorefining. Diels-Alder cycloaddition of furanic dienes with several dienophiles represents the best example of a “green” method characterized by a one hundred atom economy along with a affordable E-factor. Within this evaluation, we initially summarize the literature data on the regio- and diastereoselectivity of intermolecular Diels-Alder reactions of furfural derivatives with alkenes with the aim of establishing the current progress inside the effective production of virtually crucial low-molecular-weight merchandise. The facts provided here will be valuable and relevant to scientists in several fields, like healthcare and pharmaceutical study, polymer improvement and materials science. Keywords and phrases: biobased furans; renewable constructing blocks; plant biomass; Diels-Alder cycloaddition; selectivity; sustainable chemistry; biorefining1. Introduction To date, the development of efficient technologies for catalytic or biocatalytic conversion of renewable plant biomass into.
