Product Name :
AZ6102
Description:
AZ6102 is a potent dual TNKS1 and TNKS2 inhibitor, with IC50s of 3 nM and 1 nM, respectively, and alao has 100-fold selectivity against other PARP family enzymes, with IC50s of 2.0 μM, 0.5 μM, and >3 μM, for PARP1, PARP2, and PARP6, respectively.
CAS:
1645286-75-4
Molecular Weight:
428.53
Formula:
C25H28N6O
Chemical Name:
2-(4-6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-4-methylpyridin-3-ylphenyl)-7-methyl-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one
Smiles :
CN1C=CC2=C1N=C(NC2=O)C1C=CC(=CC=1)C1=CN=C(C=C1C)N1C[C@H](C)N[C@H](C)C1
InChiKey:
WCPTUQOMNJBIET-CALCHBBNSA-N
InChi :
InChI=1S/C25H28N6O/c1-15-11-22(31-13-16(2)27-17(3)14-31)26-12-21(15)18-5-7-19(8-6-18)23-28-24-20(25(32)29-23)9-10-30(24)4/h5-12,16-17,27H,13-14H2,1-4H3,(H,28,29,32)/t16-,17+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Obiltoxaximab Technical Information
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AZ6102 is a potent dual TNKS1 and TNKS2 inhibitor, with IC50s of 3 nM and 1 nM, respectively, and alao has 100-fold selectivity against other PARP family enzymes, with IC50s of 2.0 μM, 0.5 μM, and >3 μM, for PARP1, PARP2, and PARP6, respectively.|Product information|CAS Number: 1645286-75-4|Molecular Weight: 428.53|Formula: C25H28N6O|Chemical Name: 2-(4-6-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-4-methylpyridin-3-ylphenyl)-7-methyl-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one|Smiles: CN1C=CC2=C1N=C(NC2=O)C1C=CC(=CC=1)C1=CN=C(C=C1C)N1C[C@H](C)N[C@H](C)C1|InChiKey: WCPTUQOMNJBIET-CALCHBBNSA-N|InChi: InChI=1S/C25H28N6O/c1-15-11-22(31-13-16(2)27-17(3)14-31)26-12-21(15)18-5-7-19(8-6-18)23-28-24-20(25(32)29-23)9-10-30(24)4/h5-12,16-17,27H,13-14H2,1-4H3,(H,28,29,32)/t16-,17+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (58.Anti-Mouse CD117 Antibody Autophagy 34 mM; Need ultrasonic).PMID:33119382 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AZ6102 is a potent dual TNKS1 and TNKS2 inhibitor, with IC50s of 3 nM and 1 nM, respectively. AZ6102 alao has 100-fold selectivity against other PARP family enzymes, with IC50s of 2.0 μM, 0.5 μM, and >3 μM, for PARP1, PARP2, and PARP6, respectively. AZ6102 shows Wnt pathway inhibition in DLD-1 cells.|Products are for research use only. Not for human use.|
