Product Name :
L-733060 hydrochloride
Description:
L-733060 hydrochloride is a potent tachykinin NK1 receptor antagonist. L-733060 hydrochloride inhibits neurogenic plasma extravasation at doses that do not cause adverse cardiovascular effects in rodents and also acts as an antitumoral agent.
CAS:
148687-76-7
Molecular Weight:
439.82
Formula:
C20H20ClF6NO
Chemical Name:
(2R,3R)-3-[3,5-bis(trifluoromethyl)phenyl]methoxy-2-phenylpiperidine hydrochloride
Smiles :
Cl.FC(F)(F)C1=CC(CO[C@@H]2CCCN[C@@H]2C2C=CC=CC=2)=CC(=C1)C(F)(F)F
InChiKey:
DYEUTIUITGHIEO-JAXOOIEVSA-N
InChi :
InChI=1S/C20H19F6NO.ClH/c21-19(22,23)15-9-13(10-16(11-15)20(24,25)26)12-28-17-7-4-8-27-18(17)14-5-2-1-3-6-14;/h1-3,5-6,9-11,17-18,27H,4,7-8,12H2;1H/t17-,18-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Mirvetuximab Technical Information
Additional information:
L-733060 hydrochloride is a potent tachykinin NK1 receptor antagonist.18:0 mPEG2000 PE Metabolic Enzyme/Protease L-733060 hydrochloride inhibits neurogenic plasma extravasation at doses that do not cause adverse cardiovascular effects in rodents and also acts as an antitumoral agent.|Product information|CAS Number: 148687-76-7|Molecular Weight: 439.82|Formula: C20H20ClF6NO|Chemical Name: (2R,3R)-3-[3,5-bis(trifluoromethyl)phenyl]methoxy-2-phenylpiperidine hydrochloride|Smiles: Cl.FC(F)(F)C1=CC(CO[C@@H]2CCCN[C@@H]2C2C=CC=CC=2)=CC(=C1)C(F)(F)F|InChiKey: DYEUTIUITGHIEO-JAXOOIEVSA-N|InChi: InChI=1S/C20H19F6NO.ClH/c21-19(22,23)15-9-13(10-16(11-15)20(24,25)26)12-28-17-7-4-8-27-18(17)14-5-2-1-3-6-14;/h1-3,5-6,9-11,17-18,27H,4,7-8,12H2;1H/t17-,18-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33164657 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|L-733060 (30-300 nM) inhibits the [Ca2+]i mobilisation caused by substance P (100 nM) in a concentration-dependent manner in human tachykinin NK1 receptor-transfected CHO cells. L-733060 (2.5-20 μM; 48 and or 96 h) results in a concentration-dependent cytotoxicity in COLO 858 cells. L-733060 (10-30 μM; 24 and 48 h) inhibits MEL H0 cells proliferation with IC50s of 27.5 μM and 18.9 μM at 24 h and 48 h, respectively. L-733060 (20-50 μM; and or 72 h) inhibits COLO 679 cells growth with IC50s of 33.8 μM and 31.5 μM at 30 h and 72 h, respectively.|In Vivo:|L-733060 (10-1000 μg/kg; i.v.) inhibits electrically stimulated plasma extravasation in dura mater of rats. L-733060 (300-3000 μg/kg; i.v.) has no significant hypotensive or bradycardic effects are observed at doses of Products are for research use only. Not for human use.|
