Product Name :
Mutant IDH1-IN-2
Description:
Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.Target: Mutant IDH1Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer. More bioactivity information in Patent WO 2013046136A1 (Example 224).
CAS:
1429176-69-1
Molecular Weight:
459.53
Formula:
C24H31F2N5O2
Chemical Name:
(4S)-3-(2-[(1S)-1-4-[(4,4-difluoropiperidin-1-yl)methyl]phenylethyl]aminopyrimidin-4-yl)-4-(propan-2-yl)-1,3-oxazolidin-2-one
Smiles :
CC(C)[C@H]1COC(=O)N1C1C=CN=C(N[C@@H](C)C2C=CC(CN3CCC(F)(F)CC3)=CC=2)N=1
InChiKey:
OCZCXJFDMAWAIM-FXAWDEMLSA-N
InChi :
InChI=1S/C24H31F2N5O2/c1-16(2)20-15-33-23(32)31(20)21-8-11-27-22(29-21)28-17(3)19-6-4-18(5-7-19)14-30-12-9-24(25,26)10-13-30/h4-8,11,16-17,20H,9-10,12-15H2,1-3H3,(H,27,28,29)/t17-,20+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.Tecovirimat Description 6 nM in Fluorescence biochemical assay.ARRY-382 Activator Target: Mutant IDH1Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.PMID:32854544 More bioactivity information in Patent WO 2013046136A1 (Example 224).|Product information|CAS Number: 1429176-69-1|Molecular Weight: 459.53|Formula: C24H31F2N5O2|Chemical Name: (4S)-3-(2-[(1S)-1-4-[(4,4-difluoropiperidin-1-yl)methyl]phenylethyl]aminopyrimidin-4-yl)-4-(propan-2-yl)-1,3-oxazolidin-2-one|Smiles: CC(C)[C@H]1COC(=O)N1C1C=CN=C(N[C@@H](C)C2C=CC(CN3CCC(F)(F)CC3)=CC=2)N=1|InChiKey: OCZCXJFDMAWAIM-FXAWDEMLSA-N|InChi: InChI=1S/C24H31F2N5O2/c1-16(2)20-15-33-23(32)31(20)21-8-11-27-22(29-21)28-17(3)19-6-4-18(5-7-19)14-30-12-9-24(25,26)10-13-30/h4-8,11,16-17,20H,9-10,12-15H2,1-3H3,(H,27,28,29)/t17-,20+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (108.81 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
