Product Name :
BMS-1001 hydrochloride
Description:
BMS-1001 hydrochloride is an orally active human PD-L1/PD-1 immune checkpoint inhibitor. BMS-1001 hydrochloride exhibits low-toxicity in cells.
CAS:
2113650-04-5
Molecular Weight:
631.11
Formula:
C35H35ClN2O7
Chemical Name:
(2R)-2-[(2-[(3-cyanophenyl)methoxy]-4-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy-5-methylphenylmethyl)amino]-3-hydroxypropanoic acid; chlorohydrogen
Smiles :
Cl.CC1C=C(CN[C@H](CO)C(O)=O)C(=CC=1OCC1=CC=CC(C2C=C3OCCOC3=CC=2)=C1C)OCC1C=C(C=CC=1)C#N
InChiKey:
VKDUZONDVBDCAX-VNUFCWELSA-N
InChi :
InChI=1S/C35H34N2O7.ClH/c1-22-13-28(18-37-30(19-38)35(39)40)33(43-20-25-6-3-5-24(14-25)17-36)16-32(22)44-21-27-7-4-8-29(23(27)2)26-9-10-31-34(15-26)42-12-11-41-31;/h3-10,13-16,30,37-38H,11-12,18-21H2,1-2H3,(H,39,40);1H/t30-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Anagrelide Phosphodiesterase (PDE)
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BMS-1001 hydrochloride is an orally active human PD-L1/PD-1 immune checkpoint inhibitor. BMS-1001 hydrochloride exhibits low-toxicity in cells.|Product information|CAS Number: 2113650-04-5|Molecular Weight: 631.11|Formula: C35H35ClN2O7|Chemical Name: (2R)-2-[(2-[(3-cyanophenyl)methoxy]-4-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy-5-methylphenylmethyl)amino]-3-hydroxypropanoic acid; chlorohydrogen|Smiles: Cl.Bupivacaine Description CC1C=C(CN[C@H](CO)C(O)=O)C(=CC=1OCC1=CC=CC(C2C=C3OCCOC3=CC=2)=C1C)OCC1C=C(C=CC=1)C#N|InChiKey: VKDUZONDVBDCAX-VNUFCWELSA-N|InChi: InChI=1S/C35H34N2O7.PMID:33280463 ClH/c1-22-13-28(18-37-30(19-38)35(39)40)33(43-20-25-6-3-5-24(14-25)17-36)16-32(22)44-21-27-7-4-8-29(23(27)2)26-9-10-31-34(15-26)42-12-11-41-31;/h3-10,13-16,30,37-38H,11-12,18-21H2,1-2H3,(H,39,40);1H/t30-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 12.5 mg/mL (19.81 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1. BMS-1001 presents low toxicity towards tested cell lines and block the interaction of soluble PD-L1 with the cell surface-expressed PD-1. BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes.|References:|Skalniak L, et al. Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells. Oncotarget. 2017 Aug 7;8(42):72167-72181.Products are for research use only. Not for human use.|
