Product Name :
Benfluorex hydrochloride
Description:
Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.
CAS:
23642-66-2
Molecular Weight:
387.82
Formula:
C19H21ClF3NO2
Chemical Name:
2-(1-[3-(trifluoromethyl)phenyl]propan-2-ylamino)ethyl benzoate; chlorohydrogen
Smiles :
Cl.CC(CC1C=C(C=CC=1)C(F)(F)F)NCCOC(=O)C1C=CC=CC=1
InChiKey:
NLOALSPYZIIXEO-UHFFFAOYSA-N
InChi :
InChI=1S/C19H20F3NO2.ClH/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16;/h2-9,13-14,23H,10-12H2,1H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.|Product information|CAS Number: 23642-66-2|Molecular Weight: 387.82|Formula: C19H21ClF3NO2|Synonym:|JP-992 hydrochloride|Chemical Name: 2-(1-[3-(trifluoromethyl)phenyl]propan-2-ylamino)ethyl benzoate; chlorohydrogen|Smiles: Cl.CC(CC1C=C(C=CC=1)C(F)(F)F)NCCOC(=O)C1C=CC=CC=1|InChiKey: NLOALSPYZIIXEO-UHFFFAOYSA-N|InChi: InChI=1S/C19H20F3NO2.ClH/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16;/h2-9,13-14,23H,10-12H2,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (257.85 mM). H2O : 3.33 mg/mL (8.59 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Mecillinam Protocol |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Benfluorex hydrochloride consistently activates insulin promoter activity as measured by an increased number of GFP-positive cells. Benfluorex hydrochloride increases the number of GFP-positive cells in a dose-responsive manner and increases the level of endogenous insulin mRNA. Consistent with being HNF4α activator, Benfluorex hydrochloride stimulates HNF4α expression.Margetuximab medchemexpress Benfluorex hydrochloride alters HNF4α protease sensitivity, while the inactive control compound does not.PMID:32644722 Benfluorex hydrochloride decreases, in a concentration-dependent manner, the synthesis of acid-soluble products and ketone bodies from oleate, whereas the production of 14CO2 into citric acid cycle is markedly increased by Benfluorex hydrochloride. Benfluorex hydrochloride inhibits in a dose-dependent manner the rates of gluconeogenesis from lactate/pyruvate (10/1 nM).|References:|Lee SH, et al. Identification of alverine and benfluorex as HNF4α activators. ACS Chem Biol. 2013 Aug 16;8(8):1730-6.Kohl C, et al. Effects of benfluorex on fatty acid and glucose metabolism in isolated rat hepatocytes: from metabolic fluxes to gene expression. Diabetes. 2002 Aug;51(8):2363-8.Products are for research use only. Not for human use.|
