Product Name :
NAE-IN-M22
Description:
NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo.
CAS:
864420-54-2
Molecular Weight:
363.32
Formula:
C20H24Cl2N2
Chemical Name:
1-benzyl-N-[2-(2,4-dichlorophenyl)ethyl]piperidin-4-amine
Smiles :
ClC1C=C(Cl)C(CCNC2CCN(CC3C=CC=CC=3)CC2)=CC=1
InChiKey:
WMEXQHGRMWPOEF-UHFFFAOYSA-N
InChi :
InChI=1S/C20H24Cl2N2/c21-18-7-6-17(20(22)14-18)8-11-23-19-9-12-24(13-10-19)15-16-4-2-1-3-5-16/h1-7,14,19,23H,8-13,15H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Islatravir medchemexpress
Additional information:
NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo.|Product information|CAS Number: 864420-54-2|Molecular Weight: 363.32|Formula: C20H24Cl2N2|Chemical Name: 1-benzyl-N-[2-(2,4-dichlorophenyl)ethyl]piperidin-4-amine|Smiles: ClC1C=C(Cl)C(CCNC2CCN(CC3C=CC=CC=3)CC2)=CC=1|InChiKey: WMEXQHGRMWPOEF-UHFFFAOYSA-N|InChi: InChI=1S/C20H24Cl2N2/c21-18-7-6-17(20(22)14-18)8-11-23-19-9-12-24(13-10-19)15-16-4-2-1-3-5-16/h1-7,14,19,23H,8-13,15H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (688.Iberdomide web 10 mM; Need ultrasonic).PMID:33148628 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|M22 (0.37-90 μM; 24 h) blocks neddylation pathway selectively and suppresses degradation of CRL substrates in A549 cells. M22 (0.1-100 μM; 48 h) inhibits A549 cell proliferation completely at 30 µM (GI50=5.5 µM, GI90=19.3 µM). M22 (15-30 μM; 36 h) promotes apoptosis in A549 cell line.|In Vivo:|M22 (60 mg/kg; i.p. once daily for 14 d) inhibits tumor growth in nude mice bearing AGS xenografts. M22 (0.36-90 μM) has low acute toxicity in zebrafish model.|References:|Lu P, et, al. Discovery of a novel NEDD8 Activating Enzyme Inhibitor with Piperidin-4-amine Scaffold by Structure-Based Virtual Screening. ACS Chem Biol. 2016 Jul 15;11(7):1901-7.Products are for research use only. Not for human use.|
