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XBP-1 polyclonal antibody
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X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of misfolded proteins in the endoplasmic reticulum (ER). XBP-1 mRNA is spliced by IRE1p under ER stress, resulting in a 371 amino acid protein (XBP- 1s) which is translocated to the nucleus where it binds to the regulatory elements of downstream genes. XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones grp78 and grp94.1217486-61-7 manufacturer
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| Alternative Name X-box binding protein 1, Tax-responsive element-binding protein 5, TREB5, XBP2 | Application Flow Cytometry, ICC, WB | Application Notes Detects a band of ~60kDa by Western blot.2672512-44-4 In Vivo | Formulation Liquid.PMID:30969709 In PBS containing 0.09% sodium azide. | Host Rabbit | Immunogen Synthetic peptide corresponding to the sequence near the C-terminus of human XBP-1, spliced isoform XBP1(S). | Recommendation Dilutions/Conditions Flow Cytometry (1:50)Immunocytochemistry (1:100)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from rabbit serum. | Species Reactivity Human, Mouse | UniProt ID P17861 | Unit of Measure (UM) µg
