Product Name :
Sapropterin dihydrochloride
Description:
Sapropterin ((6R)-BH4) dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU. (1) Sapropterin dihydrochloride can stimulate TH and TPH activities leading to improved dopamine and serotonin synthesis despite persistently elevated brain phenylalanine.(2) Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet.
CAS:
69056-38-8
Molecular Weight:
314.17
Formula:
C9H17Cl2N5O3
Chemical Name:
(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-3,4,5,6,7,8-hexahydropteridin-4-one dihydrochloride
Smiles :
Cl.Cl.C[C@H](O)[C@H](O)[C@H]1CNC2N=C(N)NC(=O)C=2N1
InChiKey:
RKSUYBCOVNCALL-NTVURLEBSA-N
InChi :
InChI=1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Sapropterin ((6R)-BH4) dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU.{{Letermovir} site|{Letermovir} CMV|{Letermovir} Protocol|{Letermovir} Description|{Letermovir} custom synthesis|{Letermovir} Epigenetic Reader Domain} (1) Sapropterin dihydrochloride can stimulate TH and TPH activities leading to improved dopamine and serotonin synthesis despite persistently elevated brain phenylalanine.{{Pyridoxamine 5′-phosphate} medchemexpress|{Pyridoxamine 5′-phosphate} Metabolic Enzyme/Protease|{Pyridoxamine 5′-phosphate} Epigenetics|{Pyridoxamine 5′-phosphate} Purity & Documentation|{Pyridoxamine 5′-phosphate} Data Sheet|{Pyridoxamine 5′-phosphate} supplier} (2) Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet.PMID:31536197 |Product information|CAS Number: 69056-38-8|Molecular Weight: 314.17|Formula: C9H17Cl2N5O3|Chemical Name: (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-3,4,5,6,7,8-hexahydropteridin-4-one dihydrochloride|Smiles: Cl.Cl.C[C@H](O)[C@H](O)[C@H]1CNC2N=C(N)NC(=O)C=2N1|InChiKey: RKSUYBCOVNCALL-NTVURLEBSA-N|InChi: InChI=1S/C9H15N5O3.2ClH/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7;;/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17);2*1H/t3-,4+,6-;;/m0../s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: H2O : 125 mg/mL (397.87 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
