Product Name :
ESI-08
Description:
ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation.
CAS:
301177-43-5
Molecular Weight:
353.48
Formula:
C20H23N3OS
Chemical Name:
4-cyclohexyl-2-{[(2,5-dimethylphenyl)methyl]sulfanyl}-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
Smiles :
CC1=CC(CSC2NC(=O)C(C#N)=C(N=2)C2CCCCC2)=C(C)C=C1
InChiKey:
LSHOSZQLVLPEGG-UHFFFAOYSA-N
InChi :
InChI=1S/C20H23N3OS/c1-13-8-9-14(2)16(10-13)12-25-20-22-18(15-6-4-3-5-7-15)17(11-21)19(24)23-20/h8-10,15H,3-7,12H2,1-2H3,(H,22,23,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation.|Product information|CAS Number: 301177-43-5|Molecular Weight: 353.48|Formula: C20H23N3OS|Chemical Name: 4-cyclohexyl-2-{[(2,5-dimethylphenyl)methyl]sulfanyl}-6-oxo-1,6-dihydropyrimidine-5-carbonitrile|Smiles: CC1=CC(CSC2NC(=O)C(C#N)=C(N=2)C2CCCCC2)=C(C)C=C1|InChiKey: LSHOSZQLVLPEGG-UHFFFAOYSA-N|InChi: InChI=1S/C20H23N3OS/c1-13-8-9-14(2)16(10-13)12-25-20-22-18(15-6-4-3-5-7-15)17(11-21)19(24)23-20/h8-10,15H,3-7,12H2,1-2H3,(H,22,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{SKF 81297} site|{SKF 81297} GPCR/G Protein|{SKF 81297} Immunology/Inflammation|{SKF 81297} Protocol|{SKF 81297} Formula|{SKF 81297} custom synthesis} |Shelf Life: ≥12 months if stored properly.{{Concizumab} web|{Concizumab} Technical Information|{Concizumab} Purity|{Concizumab} supplier|{Concizumab} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33048575 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Exchange proteins directly activated by cAMP (EPAC) are a family of guanine nucleotide exchange factors that regulate a wide variety of intracellular processes in response to second messenger cAMP. ESI-08 at 25 μM has been found not to alter cAMP-induced type I and II PKA holoenzymes activation while H89, a selective PKA inhibitor, blocked the type I or II PKA activities completely.|Products are for research use only. Not for human use.|
