Product Name :
BMS-587101
Description:
BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research.
CAS:
509083-77-6
Molecular Weight:
555.43
Formula:
C26H20Cl2N4O4S
Chemical Name:
5-{[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]methyl}thiophene-3-carboxylic acid
Smiles :
CN1C(=O)N(C2C=C(Cl)C=C(Cl)C=2)C(=O)[C@@]21CN(C[C@H]2C1C=CC(=CC=1)C#N)CC1=CC(=CS1)C(O)=O
InChiKey:
NXNKJLOEGWSJGI-BKMJKUGQSA-N
InChi :
InChI=1S/C26H20Cl2N4O4S/c1-30-25(36)32(20-8-18(27)7-19(28)9-20)24(35)26(30)14-31(11-21-6-17(13-37-21)23(33)34)12-22(26)16-4-2-15(10-29)3-5-16/h2-9,13,22H,11-12,14H2,1H3,(H,33,34)/t22-,26+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Fucoxanthin} web|{Fucoxanthin} Cell Cycle/DNA Damage|{Fucoxanthin} Purity & Documentation|{Fucoxanthin} Formula|{Fucoxanthin} manufacturer|{Fucoxanthin} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BMS-587101 is a potent and orally active antagonist of leukocyte function associated antigen-1 (LFA-1). BMS-587101 has anti-inflammatory effects and can be used for rheumatoid arthritis research.|Product information|CAS Number: 509083-77-6|Molecular Weight: 555.43|Formula: C26H20Cl2N4O4S|Chemical Name: 5-{[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl]methyl}thiophene-3-carboxylic acid|Smiles: CN1C(=O)N(C2C=C(Cl)C=C(Cl)C=2)C(=O)[C@@]21CN(C[C@H]2C1C=CC(=CC=1)C#N)CC1=CC(=CS1)C(O)=O|InChiKey: NXNKJLOEGWSJGI-BKMJKUGQSA-N|InChi: InChI=1S/C26H20Cl2N4O4S/c1-30-25(36)32(20-8-18(27)7-19(28)9-20)24(35)26(30)14-31(11-21-6-17(13-37-21)23(33)34)12-22(26)16-4-2-15(10-29)3-5-16/h2-9,13,22H,11-12,14H2,1H3,(H,33,34)/t22-,26+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Lamivudine} web|{Lamivudine} Anti-infection|{Lamivudine} Technical Information|{Lamivudine} Purity|{Lamivudine} manufacturer|{Lamivudine} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.PMID:33151415 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BMS-587101 is a moderately potent inhibitor of LFA-1-mediated T-cell proliferation, with an IC50 of 20 nM in human HUVEC cells. BMS-587101 inhibits LFA-1-mediated adhesion of T cells to endothelial cells, T cell proliferation, and Th1 cytokine production. In mouse splenocytes and a mouse ICAM-1 expressing cell lines, bEND, BMS-587101 shows inhibitory activities, with an IC50 of 150 nM.|In Vivo:|In the mouse ovalbumin-induced lung inflammation model, BMS-587101 (0.1 mg/kg, 1.0 mg/kg, and 10 mg/kg; po.; twice a day) treatment significantly inhibits eosinophil accumulation.|Products are for research use only. Not for human use.|
