Product Name :
STOCK2S-26016
Description:
STOCK2S-26016 is a WNK signalling inhibitors. STOCK2S-26016 inhibits WNK4 and WNK1 with IC50s of 16 μM and 34.4 μM, respectively. STOCK2S-26016 has potential for antihypertensive research.
CAS:
332922-63-1
Molecular Weight:
333.38
Formula:
C20H19N3O2
Chemical Name:
7-ethoxy-N3-[(furan-2-yl)methyl]acridine-3,9-diamine
Smiles :
CCOC1=CC2=C(N)C3=CC=C(C=C3N=C2C=C1)NCC1=CC=CO1
InChiKey:
PGNWQNJXXLPZEL-UHFFFAOYSA-N
InChi :
InChI=1S/C20H19N3O2/c1-2-24-14-6-8-18-17(11-14)20(21)16-7-5-13(10-19(16)23-18)22-12-15-4-3-9-25-15/h3-11,22H,2,12H2,1H3,(H2,21,23)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
STOCK2S-26016 is a WNK signalling inhibitors. STOCK2S-26016 inhibits WNK4 and WNK1 with IC50s of 16 μM and 34.4 μM, respectively.{{Bombesin} MedChemExpress|{Bombesin} Bombesin Receptor|{Bombesin} Epigenetics|{Bombesin} Purity & Documentation|{Bombesin} Description|{Bombesin} supplier} STOCK2S-26016 has potential for antihypertensive research.{{Xanthine oxidase} web|{Xanthine oxidase} Immunology/Inflammation|{Xanthine oxidase} Biological Activity|{Xanthine oxidase} In Vivo|{Xanthine oxidase} supplier|{Xanthine oxidase} Cancer} |Product information|CAS Number: 332922-63-1|Molecular Weight: 333.PMID:33371758 38|Formula: C20H19N3O2|Chemical Name: 7-ethoxy-N3-[(furan-2-yl)methyl]acridine-3,9-diamine|Smiles: CCOC1=CC2=C(N)C3=CC=C(C=C3N=C2C=C1)NCC1=CC=CO1|InChiKey: PGNWQNJXXLPZEL-UHFFFAOYSA-N|InChi: InChI=1S/C20H19N3O2/c1-2-24-14-6-8-18-17(11-14)20(21)16-7-5-13(10-19(16)23-18)22-12-15-4-3-9-25-15/h3-11,22H,2,12H2,1H3,(H2,21,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|STOCK2S-26016 (10 and 30 minutes) blocks the effect of L-NAME on phosphorylated sodium-chloride cotransporter (NCC) in mDCT cells. STOCK2S-26016 (25-200 μM) drastically and dose-dependently reduces the phosphorylation of STE20/SPS1-related proline/alanine-rich protein kinase (SPAK) and NCC in mpkDCT cells. STOCK2S-26016 (50-200 μM) drastically and dose-dependently reduces the phosphorylation of SPAK and Na/K/Cl cotransporter 1 (NKCC1) in MOVAS cells.|Products are for research use only. Not for human use.|
