Product Name :
XL413 Hydrochloride(x)
Description:
BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.
CAS:
1169562-71-3
Molecular Weight:
326.18
Formula:
C14H13Cl2N3O2
Chemical Name:
12-chloro-4-[(2S)-pyrrolidin-2-yl]-8-oxa-3,5-diazatricyclo[7.4.0.0²,⁷]trideca-1(9),2(7),3,10,12-pentaen-6-one hydrochloride
Smiles :
Cl.O=C1NC(=NC2=C1OC1=CC=C(Cl)C=C12)[C@@H]1CCCN1
InChiKey:
UNDKJUKLBNARIZ-FVGYRXGTSA-N
InChi :
InChI=1S/C14H12ClN3O2.ClH/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9;/h3-4,6,9,16H,1-2,5H2,(H,17,18,19);1H/t9-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Trimethobenzamide} medchemexpress|{Trimethobenzamide} Dopamine Receptor|{Trimethobenzamide} Protocol|{Trimethobenzamide} In stock|{Trimethobenzamide} manufacturer|{Trimethobenzamide} Epigenetics}
Additional information:
BMS-863233, also known as XL-413, is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity.{{DSPC} web|{DSPC} Metabolic Enzyme/Protease|{DSPC} Epigenetics|{DSPC} Purity & Documentation|{DSPC} References|{DSPC} manufacturer} CDC7 kinase inhibitor BMS-863233 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells.PMID:35850484 CDC7, a serine-threonine kinase overexpressed in a variety of tumor cell types, plays an essential role in the initiation of DNA replication by activating origins of replication.|Product information|CAS Number: 1169562-71-3|Molecular Weight: 326.18|Formula: C14H13Cl2N3O2|Synonym:|XL-413 hydrochloride|XL 413 hydrochloride|Chemical Name: 12-chloro-4-[(2S)-pyrrolidin-2-yl]-8-oxa-3,5-diazatricyclo[7.4.0.0²,⁷]trideca-1(9),2(7),3,10,12-pentaen-6-one hydrochloride|Smiles: Cl.O=C1NC(=NC2=C1OC1=CC=C(Cl)C=C12)[C@@H]1CCCN1|InChiKey: UNDKJUKLBNARIZ-FVGYRXGTSA-N|InChi: InChI=1S/C14H12ClN3O2.ClH/c15-7-3-4-10-8(6-7)11-12(20-10)14(19)18-13(17-11)9-2-1-5-16-9;/h3-4,6,9,16H,1-2,5H2,(H,17,18,19);1H/t9-;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
