Product Name :
Rilmazafone hydrochloride
Description:
Rilmazafone hydrochloride (450191S) is a benzodiazepine (omega) ligand with sedative and hypnotic effects.
CAS:
85815-37-8
Molecular Weight:
511.79
Formula:
C21H21Cl3N6O3
Chemical Name:
5-[(2-aminoacetamido)methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide hydrochloride
Smiles :
Cl.CN(C)C(=O)C1N=C(CNC(=O)CN)N(N=1)C1C=CC(Cl)=CC=1C(=O)C1C=CC=CC=1Cl
InChiKey:
KHINGHZNENOVFD-UHFFFAOYSA-N
InChi :
InChI=1S/C21H20Cl2N6O3.ClH/c1-28(2)21(32)20-26-17(11-25-18(30)10-24)29(27-20)16-8-7-12(22)9-14(16)19(31)13-5-3-4-6-15(13)23;/h3-9H,10-11,24H2,1-2H3,(H,25,30);1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Rilmazafone hydrochloride (450191S) is a benzodiazepine (omega) ligand with sedative and hypnotic effects.|Product information|CAS Number: 85815-37-8|Molecular Weight: 511.79|Formula: C21H21Cl3N6O3|Chemical Name: 5-[(2-aminoacetamido)methyl]-1-[4-chloro-2-(2-chlorobenzoyl)phenyl]-N,N-dimethyl-1H-1,2,4-triazole-3-carboxamide hydrochloride|Smiles: Cl.CN(C)C(=O)C1N=C(CNC(=O)CN)N(N=1)C1C=CC(Cl)=CC=1C(=O)C1C=CC=CC=1Cl|InChiKey: KHINGHZNENOVFD-UHFFFAOYSA-N|InChi: InChI=1S/C21H20Cl2N6O3.ClH/c1-28(2)21(32)20-26-17(11-25-18(30)10-24)29(27-20)16-8-7-12(22)9-14(16)19(31)13-5-3-4-6-15(13)23;/h3-9H,10-11,24H2,1-2H3,(H,25,30);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Amlodipine besylate} MedChemExpress|{Amlodipine besylate} Calcium Channel|{Amlodipine besylate} Protocol|{Amlodipine besylate} Formula|{Amlodipine besylate} custom synthesis|{Amlodipine besylate} Autophagy} |Shelf Life: ≥12 months if stored properly.{{TL1A/TNFSF15 Protein, Human} medchemexpress|{TL1A/TNFSF15 Protein, Human} Biological Activity|{TL1A/TNFSF15 Protein, Human} Formula|{TL1A/TNFSF15 Protein, Human} custom synthesis|{TL1A/TNFSF15 Protein, Human} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24513027 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|When the animals are pretreated with high doses of Rilmazafone hydrochloride (450191-S; 200 or 600 mg/kg for 5 or 3 days, respectively) to induce hepatic drug-metabolizing enzymes, plasma concentrations of the metabolites after oral administration of a dose of 200 mg/kg of Rilmazafone decrease markedly depending on the induced enzyme activity. Pretreatment of rats with phenobarbital also causes decreased plasma levels of metabolites, which are almost the same as those in Rilmazafone-pretreatment. On the other hand, administration of beta-naphthoflavone to rats leads to higher plasma levels of metabolites, and slower elimination compared with those in the control and Rilmazafone or Phenobarbital pretreated rats. Rilmazafone is demonstrated to stimulate the hepatic drug-metabolizing enzymes in rats, mice and dogs, which is accompanied by a marked reduction in the pharmacological activity of pentobarbital in rats. The induction of hepatic enzyme activities by Rilmazafone is detected only when the plasma concentrations of its metabolites are very high.|Products are for research use only. Not for human use.|
