Product Name :
SB-269970 Hydrochloride
Description:
SB269970 HCl is a potent 5-HT7A antagonist (pKi = 8.9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors. It is also reported to block adrenergic α2 receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT7 receptor in the study of schizophrenia-like cognitive deficits.
CAS:
261901-57-9
Molecular Weight:
388.95
Formula:
C18H29ClN2O3S
Chemical Name:
3-{[(2R)-2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidin-1-yl]sulfonyl}phenol hydrochloride
Smiles :
Cl.CC1CCN(CC[C@H]2CCCN2S(=O)(=O)C2=CC(O)=CC=C2)CC1
InChiKey:
XQCJOYZLWFNDIO-PKLMIRHRSA-N
InChi :
InChI=1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.{{Bucillamine} medchemexpress|{Bucillamine} Protein Tyrosine Kinase/RTK|{Bucillamine} Activator|{Bucillamine} Biological Activity|{Bucillamine} Description|{Bucillamine} manufacturer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Otilonium} site|{Otilonium} GPCR/G Protein|{Otilonium} Purity & Documentation|{Otilonium} In Vivo|{Otilonium} custom synthesis|{Otilonium} Epigenetic Reader Domain}
Additional information:
SB269970 HCl is a potent 5-HT7A antagonist (pKi = 8.PMID:24025603 9) that demonstrates >50-fold binding selectivity over 5-HT5A and >250-fold selectivity over 5-HT1, 5-HT2, 5-HT4, 5-HT6, adrenergic α1, dopamine D2, and dopamine D3 receptors. It is also reported to block adrenergic α2 receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT7 receptor in the study of schizophrenia-like cognitive deficits.|Product information|CAS Number: 261901-57-9|Molecular Weight: 388.95|Formula: C18H29ClN2O3S|Chemical Name: 3-{[(2R)-2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidin-1-yl]sulfonyl}phenol hydrochloride|Smiles: Cl.CC1CCN(CC[C@H]2CCCN2S(=O)(=O)C2=CC(O)=CC=C2)CC1|InChiKey: XQCJOYZLWFNDIO-PKLMIRHRSA-N|InChi: InChI=1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
