Product Name :
Gabapentin(Neurontin)
Description:
Gabapentin is a major inhibitory neurotransmitter that functions by binding to the GABA receptors located in the spinal cord. Gabapentin is also noted to bind to a novel site on voltage-sensitive Ca2+ channels. Additionally, Gabapentin is reported to demonstrate inhibition of dopamine release from caudate nucleus, prevent neuronal cell death, and is antinociceptive. It is structurally similar to GABA and is reported in various research studies to increase GABA concentrations within the brain.
CAS:
60142-96-3
Molecular Weight:
171.24
Formula:
C9H17NO2
Chemical Name:
2-[1-(aminomethyl)cyclohexyl]acetic acid
Smiles :
NCC1(CC(O)=O)CCCCC1
InChiKey:
UGJMXCAKCUNAIE-UHFFFAOYSA-N
InChi :
InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Natamycin} web|{Natamycin} Fungal|{Natamycin} Purity & Documentation|{Natamycin} In Vivo|{Natamycin} supplier|{Natamycin} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Gabapentin is a major inhibitory neurotransmitter that functions by binding to the GABA receptors located in the spinal cord. Gabapentin is also noted to bind to a novel site on voltage-sensitive Ca2+ channels. Additionally, Gabapentin is reported to demonstrate inhibition of dopamine release from caudate nucleus, prevent neuronal cell death, and is antinociceptive. It is structurally similar to GABA and is reported in various research studies to increase GABA concentrations within the brain.|Product information|CAS Number: 60142-96-3|Molecular Weight: 171.24|Formula: C9H17NO2|Synonym:|Gabapentin|Neurontin|Gabapentine|Aclonium|Convalis|Gabapentin Hexal|Gabapentin Stada|Related CAS Number:|60142-95-2 (Gabapentin HCl)|Chemical Name: 2-[1-(aminomethyl)cyclohexyl]acetic acid|Smiles: NCC1(CC(O)=O)CCCCC1|InChiKey: UGJMXCAKCUNAIE-UHFFFAOYSA-N|InChi: InChI=1S/C9H17NO2/c10-7-9(6-8(11)12)4-2-1-3-5-9/h1-7,10H2,(H,11,12)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Water 34 mg/mL (198.55 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Gabapentin produces concentration-dependent inhibitions of the K(+)-induced [Ca(2+)](i) increase in fura-2-loaded human neocortical synaptosomes with IC50 of 17 mM and maximal inhibition of 37%. Gabapentin may bind to the Ca(2+) channel alpha 2 delta subunit to selectively attenuate depolarization-induced Ca(2+) influx of presynaptic P/Q-type Ca(2+) channels; this results in decreased glutamate/aspartate release from excitatory amino acid nerve terminals leading to a reduced activation of AMPA heteroreceptors on noradrenergic nerve terminals. Gabapentin produces alterations in the cytosolic and extracellular concentrations of several amino acids, including L-leucine, L-valine and L-phenylalanine, in rat cortical astrocytes and synaptosomes, effects that are postulated to be of pharmacological significance.{{Foralumab} medchemexpress|{Foralumab} Immunology/Inflammation|{Foralumab} Biological Activity|{Foralumab} In Vivo|{Foralumab} manufacturer|{Foralumab} Epigenetic Reader Domain} Gabapentin reduces potassium-evoked calcium influx via voltage-gated calcium channels in a mouse pituitary cell line that constitutively expresses GABAB receptors comprising the functional gb1a–gb2 subunit heterodimer.PMID:23514335 Gabapentin can increase N-methyl-d-aspartate (NMDA)-evoked currents in GABA-positive rat dorsal horn neurones in the presence of protein kinase C, possibly by increasing the glycine sensitivity of the NMDA receptor complex. Gabapentin produces a delayed allosteric enhancement of an unspecified voltage-activated potassium current in rat dorsal root ganglion neurons.|In Vivo:|Gabapentin dose-dependently (10-100 mg/kg, p.o.) blocks both static and dynamic allodynia in the rats.|References:|Field MJ, et al. Pain, 1999, 80(1-2), 391-398.Sills GJ, et al. Curr Opin Pharmacol, 2006, 6(1), 108-113.Fink K, et al. Neuropharmacology, 2002, 42(2), 229-236.Products are for research use only. Not for human use.|
