Product Name :
S3QEL-2
Description:
S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation.
CAS:
890888-12-7
Molecular Weight:
323.44
Formula:
C19H25N5
Chemical Name:
1-(3,4-dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Smiles :
CC1=CC=C(C=C1C)N1N=CC2=C(N=CN=C12)N(CCC)CCC
InChiKey:
MGIAJZSCNPODRR-UHFFFAOYSA-N
InChi :
InChI=1S/C19H25N5/c1-5-9-23(10-6-2)18-17-12-22-24(19(17)21-13-20-18)16-8-7-14(3)15(4)11-16/h7-8,11-13H,5-6,9-10H2,1-4H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Paeoniflorin} web|{Paeoniflorin} Metabolic Enzyme/Protease|{Paeoniflorin} Technical Information|{Paeoniflorin} References|{Paeoniflorin} manufacturer|{Paeoniflorin} Autophagy}
Shelf Life:
≥12 months if stored properly.{{D(+)-Galactosamine} site|{D(+)-Galactosamine} Purity & Documentation|{D(+)-Galactosamine} In Vivo|{D(+)-Galactosamine} manufacturer|{D(+)-Galactosamine} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
S3QEL-2, a suppressor of superoxide production from mitochondrial complex III, potently and selectively suppresses site IIIQo superoxide production (IC50=1.PMID:24140575 7 μM). S3QEL-2 does not affect oxidative phosphorylation, and normal electron flux. S3QEL-2 inhibits HIF-1α accumulation.|Product information|CAS Number: 890888-12-7|Molecular Weight: 323.44|Formula: C19H25N5|Chemical Name: 1-(3,4-dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine|Smiles: CC1=CC=C(C=C1C)N1N=CC2=C(N=CN=C12)N(CCC)CCC|InChiKey: MGIAJZSCNPODRR-UHFFFAOYSA-N|InChi: InChI=1S/C19H25N5/c1-5-9-23(10-6-2)18-17-12-22-24(19(17)21-13-20-18)16-8-7-14(3)15(4)11-16/h7-8,11-13H,5-6,9-10H2,1-4H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (154.59 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|S3QELs-2 protects against ROS-induced, JNK-mediated cell stress in pancreatic β-cells and S3QEL-2 strongly mitigates the oxidative stress-induced apoptosis that limits the yield of functional β-cells from intact islets.|Products are for research use only. Not for human use.|
