Product Name :
10β, 17β-dihydroxyestra-1, 4-dien-3-one
Description:
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain.
CAS:
549-02-0
Molecular Weight:
288.38
Formula:
C18H24O3
Chemical Name:
(1S,3aS,3bS,9aS,9bS,11aS)-3a,3b,9b-trihydrogenio-1,9a-dihydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
Smiles :
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43O)[C@@H]1CC[C@@H]2O
InChiKey:
UIKDFTLKOKNUJP-UGDFAFBOSA-N
InChi :
InChI=1S/C18H24O3/c1-17-8-7-15-13(14(17)4-5-16(17)20)3-2-11-10-12(19)6-9-18(11,15)21/h6,9-10,13-16,20-21H,2-5,7-8H2,1H3/t13-,14-,15-,16-,17-,18+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Crisaborole} web|{Crisaborole} Metabolic Enzyme/Protease|{Crisaborole} Protocol|{Crisaborole} In stock|{Crisaborole} custom synthesis|{Crisaborole} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{E 2012} medchemexpress|{E 2012} γ-secretase|{E 2012} Biological Activity|{E 2012} Formula|{E 2012} supplier|{E 2012} Autophagy}
Additional information:
10β,17β-dihydroxyestra-1,4-dien-3-one (DHED) is a brain-targeting bioprecursor prodrug of the main human estrogen, 17β-estradiol, alleviates hot flushes in rat models of thermoregulatory dysfunction of the brain.PMID:23453497 |Product information|CAS Number: 549-02-0|Molecular Weight: 288.38|Formula: C18H24O3|Chemical Name: (1S,3aS,3bS,9aS,9bS,11aS)-3a,3b,9b-trihydrogenio-1,9a-dihydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one|Smiles: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43O)[C@@H]1CC[C@@H]2O|InChiKey: UIKDFTLKOKNUJP-UGDFAFBOSA-N|InChi: InChI=1S/C18H24O3/c1-17-8-7-15-13(14(17)4-5-16(17)20)3-2-11-10-12(19)6-9-18(11,15)21/h6,9-10,13-16,20-21H,2-5,7-8H2,1H3/t13-,14-,15-,16-,17-,18+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (866.91 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes.|Products are for research use only. Not for human use.|
