Product Name :
BMS-911543
Description:
BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. JAK2 inhibitor BMS-911543 selectively inhibits JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.
CAS:
1271022-90-2
Molecular Weight:
432.52
Formula:
C23H28N8O
Chemical Name:
N,N-dicyclopropyl-7-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-10-ethyl-3-methyl-3,5,8,10-tetraazatricyclo[7.3.0.0²,⁶]dodeca-1,4,6,8,11-pentaene-11-carboxamide
Smiles :
CC1=CC(NC2=NC3=C(C=C(C(=O)N(C4CC4)C4CC4)N3CC)C3=C2N=CN3C)=NN1C
InChiKey:
JCINBYQJBYJGDM-UHFFFAOYSA-N
InChi :
InChI=1S/C23H28N8O/c1-5-30-17(23(32)31(14-6-7-14)15-8-9-15)11-16-20-19(24-12-28(20)3)21(26-22(16)30)25-18-10-13(2)29(4)27-18/h10-12,14-15H,5-9H2,1-4H3,(H,25,26,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{BMVC} site|{BMVC} Cell Cycle/DNA Damage|{BMVC} Purity & Documentation|{BMVC} Purity|{BMVC} manufacturer|{BMVC} Autophagy}
Shelf Life:
≥360 days if stored properly.{{Pyocyanin} site|{Pyocyanin} Metabolic Enzyme/Protease|{Pyocyanin} Protocol|{Pyocyanin} Purity|{Pyocyanin} supplier|{Pyocyanin} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BMS-911543 is an orally available small molecule targeting a subset of Janus-associated kinase (JAK) with potential antineoplastic activity. JAK2 inhibitor BMS-911543 selectively inhibits JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation.PMID:23398362 JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.|Product information|CAS Number: 1271022-90-2|Molecular Weight: 432.52|Formula: C23H28N8O|Chemical Name: N,N-dicyclopropyl-7-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-10-ethyl-3-methyl-3,5,8,10-tetraazatricyclo[7.3.0.0²,⁶]dodeca-1,4,6,8,11-pentaene-11-carboxamide|Smiles: CC1=CC(NC2=NC3=C(C=C(C(=O)N(C4CC4)C4CC4)N3CC)C3=C2N=CN3C)=NN1C|InChiKey: JCINBYQJBYJGDM-UHFFFAOYSA-N|InChi: InChI=1S/C23H28N8O/c1-5-30-17(23(32)31(14-6-7-14)15-8-9-15)11-16-20-19(24-12-28(20)3)21(26-22(16)30)25-18-10-13(2)29(4)27-18/h10-12,14-15H,5-9H2,1-4H3,(H,25,26,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
