.4 IC50233.9 36.eight 27.7 36.8 27.7 three.four 233.9 36.eight 27.7 36.eight 27.7 three.4 233.9 36.eight 27.7 three.four 233.9 3.four 233.9 3.43.four 233.9 233.9 3.four 233.9 three.four 233.9 36.eight 27.7 3.4 233.9 36.8 27.7 3.4 233.9 3.4 233.9 36.8 27.7 three.4 233.9 36.eight 27.7 42.8 42.8 36.8 27.7 36.8 27.7 36.eight 27.7 42.8 42.eight 36.eight 27.7 36.8 27.7 36.8 27.7 36.eight 27.7 42.8 36.8 27.7 36.eight 27.7 42.eight 42.8 36.8 27.7 42.8 42.eight 42.8 39.eight 39.eight 42.8 42.8 42.8 39.8 39.8 42.eight 42.8 42.8 39.8 42.eight 42.eight 39.8 39.8 42.eight 39.eight 39.eight 9.0 12.9 9.0 12.9 39.eight 9.0 12.9 9.0 12.9 39.8 39.eight 39.eight 39.eight 39.eight 9.0 12.9 39.8 39.8 39.eight 9.0 12.9 9.0 12.9 39.eight 9.0 12.9 39.8 four.four 6.five four.four six.five 9.0 12.9 four.4 6.5 4.4 6.five 9.0 12.9 9.0 12.9 four.four six.5 9.0 12.9 9.0 12.9 9.0 12.9 9.04.4 12.9 9.0 12.9 9.0 12.9 4.four six.five 6.five 9.0 12.9 four.four six.five 9.0 12.9 9.0 12.9 four.4 6.five 47.eight 76.0 47.8 76.0 four.4 six.5 47.eight 76.0 47.8 76.0 four.four six.five four.4 six.five 47.8 76.0 4.4 six.five 4.4 6.five six.5 47.8 76.0 four.44.four 6.5 47.8 76.0 four.four six.five four.four six.five 47.8 76.0 four.four six.five 47.eight 76.0 13.four 17.8 47.eight 76.0 13.4 17.8 13.four 17.eight 47.8 76.0 13.four 17.eight 47.eight 76.0 47.8 76.0 47.eight 76.0 47.eight 76.0 13.four 17.eight 47.8 76.0 47.8 76.0 47.eight 76.0 13.4 17.8 13.4 17.8 47.eight 76.0 13.4 17.eight 47.eight 76.0 13.four 17.8 28.1 27.five 13.4 17.8 28.1 27.5 28.1 27.5 13.4 17.eight 28.1 27.five 13.four 17.8 13.4 17.eight 13.four 17.eight 13.4 17.8 13.4 17.8 28.1 27.five 13.four 17.eight 13.4 17.8 28.1 27.5 28.1 27.5 13.4 17.eight 28.1 27.five 13.four 17.8 28.1 27.five 28.1 27.five 355.7 300.three 355.7 300.3 28.1 27.5 355.7 300.three 355.7 300.3 28.1 27.five 28.1 27.five 28.1 27.5 28.1 27.5 28.1 27.five 355.7 300.3 28.1 27.5 28.1 27.5 355.7 300.3 355.7 300.3 28.1 27.5 355.7 300.3 355.7 300.three 355.7 300.three 230.3 256.7 230.three 256.7 355.7 300.three 230.3 256.7 355.7 300.three 230.3 256.7 355.7 300.three 355.7 300.three 355.7 300.3 355.7 300.3 230.3 256.7 355.7 300.three 355.7 300.3 230.3 256.7 230.three 256.7 355.7 300.3 230.three 256.7 230.three 256.7 230.three 256.7 230.three 256.7 314.two 421.5 314.two 421.five 230.three 256.7 314.2 421.five 230.3 256.7 314.two 421.5 230.three 256.7 230.three 256.7 230.three 256.7 230.three 256.7 314.2 421.5 230.3 256.7 230.3 256.7 314.2 421.5 314.2 421.5 314.two 421.5 230.three 256.7 314.2 421.5 314.2 421.5 314.two 421.5 47.9 36.7 47.9 36.7 47.9 36.7 314.two 421.five 314.2 421.5 47.9 36.7 314.two 421.5 314.2 421.five 314.two 421.5 47.9 36.7 314.2 421.5 314.two 421.5 47.9 36.7 47.9 36.7 47.9 36.7 314.two 421.five 47.9 36.7 47.9 36.7 47.9 36.7 177.5 287.8 177.5 287.8 47.9 36.7 177.5 287.eight 47.9 36.7 177.5 287.8 47.9 36.7 47.9 36.7 47.9 36.7 47.9 36.7 177.5 287.eight 47.9 36.7 47.9 36.7 177.five 287.8 177.5 287.eight 177.five 287.eight 47.9 36.7 177.five 287.8 362.four 318.four 177.five 287.eight 362.4 318.4 362.four 318.four 362.4 318.four 177.five 287.8 177.five 287.eight 177.five 287.eight 362.four 318.four 177.5 287.8 362.4 318.4 177.5 287.8 177.five 287.eight 177.five 287.eight 362.4 318.4 362.4 318.four 177.five 287.eight 362.4 318.four 362.four 318.four 362.four 318.four 362.four 318.4 362.4 318.four 362.four 318.4 362.four 318.4 362.four 318.4 362.four 318.4 362.four 318.four 362.four 318.Mar. Drugs 2021, 19,23 ofRemoval of your methyl group at R3 led to a reduce in potency against both pathogens (89). This outcome was certainly expected for the Mtb iNOS Formulation target ALK6 site ClpC1-NTD [96]. This group interacts well with the target, that is also closely packed together with the indole motif of the tryptophan core. However, it is not however clear why deletion of this methyl residue impairs activity towards Pfalcp. Modifications of R4 on -methoxyphenylalanine four were also well tolerated (90). The amino- and azido-derivatives 90a and 90b have been equipotent to cyclomarin C, plus the nitro compound 90c was even twice as active. Only in the case of bromo derivative 90d was a substantial drop in activity observed. 7. Conclusions The ilamycins/r
