Iption element [34]. This gene is expressed in embryonic stem (ES) cells, germ cells [35], and adult human stem cells [36], whilst it helps to maintain an undifferentiated state and to prevent differentiation [37,38]. In this study, we showed that OCT4 expression is usually CCT367766 custom synthesis induced by ten nM 17-beta-estradiol in MCF-7 mammospheres. Usually estrogens act via two sorts of pathways, namely, an estrogen receptordependent pathway and an estrogen receptor-independent pathway inside the cells [39]. Estrogens bind to the estrogen receptor of the nucleus to form ER-estrogen complexes inside the ER-dependent pathway. These complexes may well influence, straight, OCT4 expression by binding towards the OCT4 gene
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