N Table 1). The particular use of these data for the present study did not warrant further participant consent, with de-identified health data not considered to be protected health information under currentPLOS ONE | DOI:10.1371/journal.pone.0142388 November 5,3 /Mild Cognitive Impairment InternationallyTable 1. Contributing studies. Study Cognitive Function Ageing Studies Einstein Aging Study Etude j.addbeh.2012.10.012 Sant?Psychologique Pr alence PD0325901 web Risques et Traitement Hong Kong Memory and Ageing Prospective Study Invecchiamento Cerebrale in Abbiategraso Monongahela Valley Independent Elders Survey Personality and Total Health Through Life Project Singapore Longitudinal Ageing Studies Sydney Memory and Ageing Study Washington Heights Inwood and Columbia Aging Project Zaragoza Dementia Depression Project doi:10.1371/journal.pone.0142388.t001 Abbreviation CFAS EAS ESPRIT HK-MAPS Invece.Ab MoVIES PATH SLAS Sydney MAS WHICAP ZARADEMP Country UK USA France Hong Kong Italy USA Australia Singapore Australia USA Spain Reference Brayne et al. [23] Katz et al. [16] Ritchie et al. [24] Wong et al. [25] Guaita et al. [26] Ganguli et al. [27] Anstey et al. [28] Feng et al. [29, 30] Sachdev et al. [31] Tang et al. [32] Lobo et al. [33]Table 2. Sample characteristics. Characteristic CFAS EAS ESPRIT HK-MAPS Invece.Ab MoVIES Sydney WHICAP MAS (N = 1267) (N = 1276) (N = 1973) (N = 3950) (N = 1037) (N = 3991) PATH SLAS ZARADEMP (N = 4415) 73.4 ?9.3 60?(N = 2050) (N = 1954) (N = 2189) (N = 786) Age (yrs) Mean ?SD Range Sex Female Male Education Less than 195 (9.5) completed high school Completed high school 1399 (68.2) 428 (21.9) 1289 (62.9) 1191 (61.0) 1277 (58.3) 75.8 ?7.3 78.3 ?5.4 64?05 63?73.1 ?5.6 72.3 ?7.2 71.2 ?1.3 74.2 ?5.4 70.6 ?1.5 68.5 ?6.3 78.8 ?4.8 76.4 ?6.5 65?6 60?6 70?5 66?7 68?4 60?7 70?0 63?422 (53.7) 684 (54.0) 775 (60.7) 953 (48.3) 2382 (60.3) 1568 (39.7)572 (55.2) 2684 (67.3) 2518 (57.0) 465 (44.8) 1307 (32.7) 1897 (43.0)761 (37.1) 763 (39.0)912 (41.7) 364 (46.3) 583 (46.0) 501 (39.3) 1020 (51.7) 550 (25.1) 686 (87.3) 1150 (90.8) 911 (41.6) 49 (6.2) 210 (9.6) 8 (1.0) 90 (7.1) NAa 27 (2.1) 0 (0.0) White500 (39.2) 466 (23.6) 3449 (87.3) 544 (42.6) 202 (10.2) 73 (1.8) 193 (15.1) 610 (30.9) 265 (6.7) 39 (3.1) 0 (0.0) White 674 (34.2) 161 (4.1) 21 (1.1) White 2 (0.1) Chinese437 (42.1) 2163 (54.2) 3838 (86.9)906 (46.4)177 (17.1) 733 (18.4) 112 (10.8) 480 (12.0) 311 (30.0) 605 (15.2) 0 (0.0) White 10 (0.3) Hispanic (48 ); Black (30 ); White (21 )128 (2.9) 281 (6.4) 131 (3.0) 37 (0.8) WhiteTechnical/ 286 (14.0) 97 (5.0) college Vesnarinone structure diploma University degree Missing data Race/ethnicity 148 (7.2) 22 (1.1) White 478 (24.5) 45 (2.3) White (67 ); Black (27 )516 (23.6) 42 (5.3) 2 (0.1) White 1 (0.1) ChineseNA = not applicable. Data are n ( ) unless stated otherwise. N is for the contributed sample that includes individuals from the full study sample without j.jebo.2013.04.005 dementia and with no missing data on the baseline dementia, age and sex variables. Age corresponds to the assessment wave for which data were provided: baseline for all studies except MoVIES (wave 2) and PATH (wave 3). For race/ethnicity, the sample was comprised entirely or predominantly of that shown unless otherwise indicated.aTechnical/college diploma could not be distinguished from Completed high school for Invece.Ab.doi:10.1371/journal.pone.0142388.tPLOS ONE | DOI:10.1371/journal.pone.0142388 November 5,4 /Mild Cognitive Impairment Internationallyresearch principles (e.g., as per the Privacy Rule proposed by th.N Table 1). The particular use of these data for the present study did not warrant further participant consent, with de-identified health data not considered to be protected health information under currentPLOS ONE | DOI:10.1371/journal.pone.0142388 November 5,3 /Mild Cognitive Impairment InternationallyTable 1. Contributing studies. Study Cognitive Function Ageing Studies Einstein Aging Study Etude j.addbeh.2012.10.012 Sant?Psychologique Pr alence Risques et Traitement Hong Kong Memory and Ageing Prospective Study Invecchiamento Cerebrale in Abbiategraso Monongahela Valley Independent Elders Survey Personality and Total Health Through Life Project Singapore Longitudinal Ageing Studies Sydney Memory and Ageing Study Washington Heights Inwood and Columbia Aging Project Zaragoza Dementia Depression Project doi:10.1371/journal.pone.0142388.t001 Abbreviation CFAS EAS ESPRIT HK-MAPS Invece.Ab MoVIES PATH SLAS Sydney MAS WHICAP ZARADEMP Country UK USA France Hong Kong Italy USA Australia Singapore Australia USA Spain Reference Brayne et al. [23] Katz et al. [16] Ritchie et al. [24] Wong et al. [25] Guaita et al. [26] Ganguli et al. [27] Anstey et al. [28] Feng et al. [29, 30] Sachdev et al. [31] Tang et al. [32] Lobo et al. [33]Table 2. Sample characteristics. Characteristic CFAS EAS ESPRIT HK-MAPS Invece.Ab MoVIES Sydney WHICAP MAS (N = 1267) (N = 1276) (N = 1973) (N = 3950) (N = 1037) (N = 3991) PATH SLAS ZARADEMP (N = 4415) 73.4 ?9.3 60?(N = 2050) (N = 1954) (N = 2189) (N = 786) Age (yrs) Mean ?SD Range Sex Female Male Education Less than 195 (9.5) completed high school Completed high school 1399 (68.2) 428 (21.9) 1289 (62.9) 1191 (61.0) 1277 (58.3) 75.8 ?7.3 78.3 ?5.4 64?05 63?73.1 ?5.6 72.3 ?7.2 71.2 ?1.3 74.2 ?5.4 70.6 ?1.5 68.5 ?6.3 78.8 ?4.8 76.4 ?6.5 65?6 60?6 70?5 66?7 68?4 60?7 70?0 63?422 (53.7) 684 (54.0) 775 (60.7) 953 (48.3) 2382 (60.3) 1568 (39.7)572 (55.2) 2684 (67.3) 2518 (57.0) 465 (44.8) 1307 (32.7) 1897 (43.0)761 (37.1) 763 (39.0)912 (41.7) 364 (46.3) 583 (46.0) 501 (39.3) 1020 (51.7) 550 (25.1) 686 (87.3) 1150 (90.8) 911 (41.6) 49 (6.2) 210 (9.6) 8 (1.0) 90 (7.1) NAa 27 (2.1) 0 (0.0) White500 (39.2) 466 (23.6) 3449 (87.3) 544 (42.6) 202 (10.2) 73 (1.8) 193 (15.1) 610 (30.9) 265 (6.7) 39 (3.1) 0 (0.0) White 674 (34.2) 161 (4.1) 21 (1.1) White 2 (0.1) Chinese437 (42.1) 2163 (54.2) 3838 (86.9)906 (46.4)177 (17.1) 733 (18.4) 112 (10.8) 480 (12.0) 311 (30.0) 605 (15.2) 0 (0.0) White 10 (0.3) Hispanic (48 ); Black (30 ); White (21 )128 (2.9) 281 (6.4) 131 (3.0) 37 (0.8) WhiteTechnical/ 286 (14.0) 97 (5.0) college diploma University degree Missing data Race/ethnicity 148 (7.2) 22 (1.1) White 478 (24.5) 45 (2.3) White (67 ); Black (27 )516 (23.6) 42 (5.3) 2 (0.1) White 1 (0.1) ChineseNA = not applicable. Data are n ( ) unless stated otherwise. N is for the contributed sample that includes individuals from the full study sample without j.jebo.2013.04.005 dementia and with no missing data on the baseline dementia, age and sex variables. Age corresponds to the assessment wave for which data were provided: baseline for all studies except MoVIES (wave 2) and PATH (wave 3). For race/ethnicity, the sample was comprised entirely or predominantly of that shown unless otherwise indicated.aTechnical/college diploma could not be distinguished from Completed high school for Invece.Ab.doi:10.1371/journal.pone.0142388.tPLOS ONE | DOI:10.1371/journal.pone.0142388 November 5,4 /Mild Cognitive Impairment Internationallyresearch principles (e.g., as per the Privacy Rule proposed by th.