AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR4093p, miR652, miRsubmit your manuscript | www.dovepress.commiR133a, miR-148bmiRmiR-148b, miR376c, miR4093p, miRmiR-155, miRmiRmiRNotes: This is a representative sample of 20 recent studies located on a PubMed query (breast cancer blood miRNA miR) that describe individual miRNAs or miRNA signatures obtaining prospective application for early illness detection. Studies with fewer than 20 BC situations had been excluded. Though these signatures mainly reflect higher amounts of circulating miRNAs, some miRNAs are detected at decrease levels in blood samples of BC individuals. Blood collection was performed ahead of surgery unless otherwise indicated. miRNAs shown in bold indicate a recurrent presence in at the very least three independent studies. Abbreviations: BC, breast cancer; DCiS, ductal carcinoma in situ; eR, estrogen receptor; LN, lymph node status; miRNA, microRNA; qRTPCR, quantitative realtime polymerase chain reaction.Breast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable two miRNArelated risk loci associated with BCGene locus MIR27A SNP rs895919 *C Comments Population Asians Caucasians Jewish BRCA2 carriers Caucasian Asians Caucasians Chinese (young) Chinese Asians Caucasians African Americans African Americans european Americans Chinese Chinese African Americans european Americans African Americans european Americans italian Caucasians Chinese Asians Caucasians Asians Asians Caucasians Chinese Asians Caucasians Chinese Asians Caucasians African Americans African Americans Korean italian and German Asians Caucasians Brazilian Caucasian Chinese and Korean Chinese Chinese African Americans european Americans Asians Caucasians African Americans european Americans African dar.12324 increased danger Decreased risk No risk association Decreased threat Decreased danger Decreased risk No danger association No threat association increased survival No threat association Decreased overall threat enhanced risk increased risk No threat association elevated overall danger Decreased risk of eR+ BC No danger association earlier age of onset No threat association No danger association No threat association No threat association Decreased risk (C allele) No danger association No danger association No threat association No threat association No threat association No danger association No threat association No risk association Decreased threat Lowered danger Survival of HeR2+ cases No risk association Decreased danger No risk association Decreased danger Decreased risk Decreased threat increased threat enhanced threat No risk association No risk association No danger association No risk association Decreased threat of eR- BC No threat association enhanced survival improved risk of eR- BC No risk association No danger association increased overall danger No threat association No risk association Reference 141 142 143 144 35 34 31 145 33 38 38 33 33 146 147 83 38 144 31 36 38 36 31 145 145 148 37 141 149 147 32 36 83 33 31 33 145 33 33rs895819 A/GpremiRNA premiRNA premiRNA premiRNAMIR34B cluster MIR100 MIR101-2 MIR106B MIR122A MIR146Ars4938723 T/C rs1834306 G/A rs1053872 C/G rs462480 A/C rs1527423 A/G rs17669 A/G rs2910164 G/C Main transcript Primary transcriptMIRrs2292832 T/GMIR185 MIR196A-rs2008591 C/T rs887205 A/G rs11614913 T/CMIR204 MIR206 MIR219 MIR331 MIRrs7861254 G rs6920648 A/G rs107822 G/A rs.AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR4093p, miR652, miRsubmit your manuscript | www.dovepress.commiR133a, miR-148bmiRmiR-148b, miR376c, miR4093p, miRmiR-155, miRmiRmiRNotes: This really is a representative sample of 20 current research found on a PubMed query (breast cancer blood miRNA miR) that describe person miRNAs or miRNA signatures getting possible application for early illness detection. Research with fewer than 20 BC circumstances were excluded. Whilst these signatures primarily reflect higher amounts of circulating miRNAs, some miRNAs are detected at reduce levels in blood samples of BC patients. Blood collection was performed just before surgery unless otherwise indicated. miRNAs shown in bold indicate a recurrent presence in at the least 3 independent research. Abbreviations: BC, breast cancer; DCiS, ductal carcinoma in situ; eR, estrogen receptor; LN, lymph node status; miRNA, microRNA; qRTPCR, quantitative realtime polymerase chain reaction.Breast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable 2 miRNArelated risk loci associated with BCGene locus MIR27A SNP rs895919 *C Comments Population Asians Caucasians Jewish BRCA2 carriers Caucasian Asians Caucasians Chinese (young) Chinese Asians Caucasians African Americans African Americans european Americans Chinese Chinese African Americans european Americans African Americans european Americans italian Caucasians Chinese Asians Caucasians Asians Asians Caucasians Chinese Asians Caucasians Chinese Asians Caucasians African Americans African Americans Korean italian and German Asians Caucasians Brazilian Caucasian Chinese and Korean Chinese Chinese African Americans european Americans Asians Caucasians African Americans european Americans African a0023781 Americans African Americans european Americans African Americans european Americans Asians Caucasians Clinical observation No threat association Protective dar.12324 improved danger Decreased threat No danger association Decreased danger Decreased threat Decreased threat No danger association No threat association increased survival No risk association Decreased all round threat increased threat increased danger No risk association elevated all round danger Decreased threat of eR+ BC No danger association earlier age of onset No threat association No danger association No risk association No threat association Decreased threat (C allele) No risk association No threat association No risk association No danger association No threat association No threat association No threat association No risk association Decreased danger Reduced risk Survival of HeR2+ circumstances No threat association Decreased risk No danger association Decreased risk Decreased threat Decreased threat improved threat enhanced danger No danger association No threat association No risk association No danger association Decreased danger of eR- BC No threat association improved survival improved danger of eR- BC No risk association No danger association increased overall threat No danger association No threat association Reference 141 142 143 144 35 34 31 145 33 38 38 33 33 146 147 83 38 144 31 36 38 36 31 145 145 148 37 141 149 147 32 36 83 33 31 33 145 33 33rs895819 A/GpremiRNA premiRNA premiRNA premiRNAMIR34B cluster MIR100 MIR101-2 MIR106B MIR122A MIR146Ars4938723 T/C rs1834306 G/A rs1053872 C/G rs462480 A/C rs1527423 A/G rs17669 A/G rs2910164 G/C Key transcript Principal transcriptMIRrs2292832 T/GMIR185 MIR196A-rs2008591 C/T rs887205 A/G rs11614913 T/CMIR204 MIR206 MIR219 MIR331 MIRrs7861254 G rs6920648 A/G rs107822 G/A rs.
