Since KGF plays a central role in epithelial-mesenchymal interactions in lungs, our data suggest that an alteration in miR-155 expression level may have important pathophysiological impacts during acute lung injury or pulmonary diseases. Several studies have reported that miR-155 expression is modulated in a number of physiological and 16494499 pathological processes such as hematopoiesis, immunity, tumorigenesis and inflammation. MiR-155 has been identified as a component of the primary response to several inflammatory mediators in different cell types. It has been shown that miR-155 is induced by lipopolysaccharide, interferon, polyriboinosinic-polyribocytidylic acid or TNF-a in monocytes, macrophages and dendritic cells. In addition, nuclear factor-kappa B and AP-1 transcription factors have been shown to regulate miR-155 expression. Our results showing the stimulation of miR-155 by IL-1b and TNF-a in human pulmonary fibroblasts fit well with these studies. These data are consistent with the high levels of miR-155 detected in synovial fibroblasts from Rheumatoid Arthritis patients, an autoimmune disorder associated with high inflammation at joint level. Our observation showing an increased level of expression of miR-155 in a mouse model of lung fibrosis NP-031112 biological activity suggests a potential role for miR-155 during this physio-pathological process. The precise cellular location of miR-155 transcript has not been performed yet. It is tempting to speculate that the weak induction of KGF after stimulation by IL-1 observed in fibroblasts derived from ACCESSION NUMBER DESCRIPTION Log2 Ratio 24 h NM_058172 NM_001186;NM_206866 NM_001025105;NM_001892 NM_002009 NM_002009;AK054997 NM_002107 NM_018509 NM_145342;NM_015093 NM_014904 NM_001007068;NM_001007069; NM_001007070;NM_005625;NM_001007067 NM_001033578;NM_170709;NM_013257 NM_014765 NM_018718 NM_020856 NM_030927 NM_145690;NM_003406 Leucine rich repeat containing 59, mRNA. Mitogen-activated protein kinase kinase kinase 7 interacting protein 2, mRNA. RAB11 family interacting protein 2 , mRNA. Syndecan binding protein , 
transcript variant 2, mRNA. Serum/glucocorticoid regulated kinase family, member 3, transcript variant 1, mRNA. 17984313 Translocase of outer mitochondrial membrane 20 homolog , mRNA. Testis specific, 14, mRNA. Teashirt zinc finger homeobox 3, mRNA. Tetraspanin 14, mRNA. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, transcript variant 1, mRNA. H3 histone, family 3A, mRNA. cDNA FLJ30435 fis, clone BRACE2009031, weakly similar to KERATINOCYTE GROWTH FACTOR PRECURSOR. Fibroblast growth factor 7 , mRNA. Casein kinase 1, alpha 1, transcript variant 2, mRNA. BTB and CNC homology 1, basic leucine zipper transcription factor 1, transcript variant 1, mRNA. Anthrax toxin receptor 2, mRNA. 21.30 20.85 20.98 20.78 21.12 21.73 20.96 21.26 21.37 20.99 20.63 20.67 21.03 20.84 21.04 20.68 48 h 21.54 21.12 21.29 21.33 21.55 22.31 20.98 21.34 21.50 22.66 20.59 20.86 21.29 20.92 20.76 21.78 Adj.P.Val 24 h 1.49E-05 2.78E-04 1.53E-05 2.71E-03 6.86E-04 3.64E-04 6.91E-04 1.52E-04 2.92E-04 1.42E-03 1.20E-03 3.50E-04 2.08E-05 1.62E-03 1.08E-05 5.39E-05 Name ID RNG UNIGENE ID 48 h 3.82E-06 4.75E-05 1.52E-06 9.21E-05 3.12E-05 2.61E-05 2.12E-04 1.81E-04 8.41E-05 3.26E-06 7.22E-04 3.26E-05 3.96E-06 4.30E-04 6.68E-06 3.88E-07 ANTXR2 49597 Hs.162963 BACH1 90782 Hs.154276 CSNK1A1 91649 Hs.529862 FGF7 129551 Hs.567268 FGF7 172697 Hs.567268 H3F3A 91945 Hs.546259 7 LRRC59 32621 Hs.370927 MAP3K7IP2 163253 H
