Clinical use as drugs for a number of diseases are associated
Using a technique pioneered by Pelham and Wang and refined by others, the role...
Here we highlight the importance of human cell-based functional assays to investigate drug efficiency
translation of cap-dependent mRNAs encoding cell cycle regulators and anti-apoptotic proteins. Eukaryotic initiation factor...
The lack of activity displayed by the other four compounds is likely to be attributed
These MMPs are released by local cells as well as by infiltrating leukocytes and...
With the negatively charged residues lining the sub-pockets of the hPC6 active
However, the number of potent and selective inhibitors remains small and the community still...
Selection of JAR spheroids of size similar to human blastocyst were done
Local application in bone and controlled release of C3 proteins or C3-transporters from orthopaedic...
Studies were conducted in accordance with the principles described
we have found that the great majority of pancreatic cancer cell lines have very...
Throughput virtual screening use scoring functions for evaluating
In addition, PCs including PC6 also play an important role in HIV infection. Therefore,...
Rapid changes in BNP levels reflect an adequate response to CHF therapy
Quantum mechanical calculation is also conducted for analysis of electrostatic characteristics of compounds. Inspection...
Caused a significant increase in the concentration of the tubular injury marker b2-microglobulin
The ability of PP1 to dephosphorylate RyR was demonstrated in both skeletal and cardiac...
The main elimination route of the first generation of approved DPP-4 inhibitors is via the kidney
Previous studies of ours suggest that TKI-dependent combination therapy likely represents a potentially useful...